超声引导氩氦刀治疗晚期非小细胞肺癌合并锁骨上淋巴结转移患者的临床观察  

Ultrasound-guided argon-helium knife cryoablation for the treatment of advanced non-small cell lung cancer with supraclavicular lymph node metastases:a clinical observation

作　　者：高志强 王雷[2] 滕家俊 顾平 张波[1] 马美丽 王韡旻 施春雷 钟华[1] GAO Zhiqiang;WANG Lei;TENG Jiajun;GU Ping;ZHANG Bo;MA Meili;WANG Weimin;SHI Chunlei;ZHONG Hua(Department of Respiratory Medicine,Shanghai Municipal Chest Hospital(Affiliated Chest Hospital of Shanghai Jiao Tong University School of Medicine),Shanghai 200030,China)

机构地区：[1]上海市胸科医院/上海交通大学医学院附属胸科医院呼吸内科,上海200030 [2]上海市胸科医院/上海交通大学医学院附属胸科医院超声科,上海200030

出　　处：《介入放射学杂志》2024年第12期1308-1312,共5页Journal of Interventional Radiology

摘　　要：目的初步探讨超声引导氩氦刀冷冻消融治疗晚期非小细胞肺癌合并锁骨上淋巴结转移的近期疗效。方法14例晚期非小细胞肺癌合并锁骨上淋巴结转移的患者在静脉化疗或靶向治疗的基础上,应用超声引导氩氦刀冷冻消融治疗锁骨上转移的淋巴结,观察其近期治疗效果及不良反应。结果14例患者均在超声引导下成功实施氩氦刀冷冻消融治疗,整体有效率为78.6%,患者局部受压症状好转,QLQ-C30生命质量量表评估得分较治疗前有所提高。术后发热和穿刺局部的疼痛作为氩氦刀冷冻治疗常见的伴随症状,在对症治疗后数天内症状会减轻或消失。结论超声引导氩氦刀冷冻消融是一种有效的对晚期非小细胞肺癌锁骨上淋巴结转移进行局部姑息治疗方法,并能对肿瘤治疗过程中的变化进行实时监测和治疗效果评估。短期临床症状可在术后得到改善,患者的生存质量有所提高。Objective To investigate the short-term efficacy of ultrasound-guided argon-helium knife cryoablation for the treatment of advanced non-small cell lung cancer with supraclavicular lymph node metastases.Methods A total of 14 patients with advanced non-small cell lung cancer complicated by supraclavicular lymph node metastases were treated with ultrasound-guided argon-helium knife cryoablation on the basis of intravenous chemotherapy or targeted therapy.The short-term therapeutic effect and adverse reactions were analyzed.Results All the 14 patients were successfully treated with argon-helium knife cryoablation under ultrasound guidance.The overall effective rate was 78.6%,and the local compression symptoms of the patients were improved.The scores evaluated by the QLQ-C30 scale were improved when compared with preoperative values.The postoperative fever and local pain of puncture site,which were the common accompanying symptoms of argon-helium knife cryoablation,were relieved or disappeared within a few days after symptomatic treatment.Conclusion Ultrasound-guided argon-helium knife cryoablation is an effective method for local palliative treatment of advanced non-small cell lung cancer with supraclavicular lymph node metastases,which can monitor the real-time changes of lesion and evaluate the therapeutic effect in the treatment course.The clinical symptoms can be relieved within a short time after treatment,and the quality of life of patients will also be improved.

关 键 词：氩氦刀 晚期非小细胞肺癌 超声引导 锁骨上淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤]