超声引导下微波消融联合^(125)I粒子植入治疗结直肠肝转移癌的效果  

The efficacy of ultrasound-guided microwave ablation combined with^(125)I seed implantation for the treatment of liver metastases from colorectal cancer

作　　者：韩彬[1] 孟艳[2] 杭菁[3] HAN Bin;MENG Yan;HANG Jing(Department of Ultrasound,Liyang Municipal People′s Hospital,Liyang,Jiangsu Province 213300,China)

机构地区：[1]溧阳市人民医院超声科,江苏溧阳213300 [2]江苏省中西医结合医院超声科 [3]江苏省人民医院超声科

出　　处：《介入放射学杂志》2024年第12期1325-1329,共5页Journal of Interventional Radiology

基　　金：江苏省基础研究计划(青年基金)项目(BK20210081)。

摘　　要：目的探讨超声引导下微波消融联合^(125)I粒子植入治疗巨大肝转移癌的效果。方法纳入2017年1月至2021年1月在溧阳市人民医院确诊的巨大肝转移癌患者76例,根据治疗方法分为两组,每组38例。对照组行超声引导下微波消融术,观察组采用超声引导下微波消融术联合^(125)I粒子植入治疗。比较两组患者治疗6个月的疾病控制率,治疗前和治疗6个月的肿瘤标志物[糖类抗原125(CA125)、糖类抗原153(CA153)]和肝功能指标(AST、ALT、TBil),并记录患者2年内的无进展生存期(PFS)。结果观察组的疾病控制率高于对照组,治疗后的肿瘤标志物水平均低于对照组,治疗后两组患者的肝功能指标均高于治疗前,且观察组PFS比对照组延长,差异均有统计学意义(均P<0.05)。两组治疗后的肝功能指标相比,差异无统计学意义(P>0.05)。结论超声引导下微波消融联合^(125)I粒子植入治疗巨大肝转移癌可提高临床疗效,延长患者生存期。Objective To discuss the clinical efficacy of ultrasound-guided microwave ablation(MWA)combined with^(125)I seed implantation for the treatment of huge liver metastases from colorectal cancer.Methods A total of 76 patients with huge liver metastases,whose diagnosis was confirmed at the Liyang Municipal People′s Hospital of China from January 2017 to January 2021,were enrolled in this study.According to the therapeutic scheme,the patients were divided into study group(n=38)and control group(n=38).Ultrasound-guided MWA was adopted for the patients of the control group,while ultrasound-guided MWA combined with^(125)I seed implantation was carried out for the patients of the study group.The postoperative 6-month disease control rate(DCR),the preoperative and postoperative 6-month tumor marker levels(including CA125 and CA153),and liver function indicators(including AST,ALT and TBiL)were compared between the two groups.In addition,the 2-year progression-free survival(PFS)of both groups was calculated.Results In the study group the DCR was higher than that in the control group,the postoperative tumor marker levels were lower than those in the control group.After treatment,the liver function indicators in both groups were increased when compared with the preoperative values,and PFS in the study group was longer than that in the control group,the differences were statistically significant(all P<0.05).No statistically significant differences in the postoperative liver function indicators existed between the two groups(P>0.05).Conclusion For the treatment of huge liver metastases,ultrasound-guided MWA combined with^(125)I seed implantation can improve the clinical therapeutic efficacy and prolong patient′s survival time.

关 键 词：超声引导下微波消融 ^(125)I放射性粒子 巨大肝转移癌 疾病控制率 

分 类 号：R735.7[医药卫生—肿瘤]