食管支架治疗晚期食管癌的研究进展  

Research progress in esophageal stenting for the treatment of advanced esophageal cancer

作　　者：徐浩洋 朱悦琦 程英升[1] XU Haoyang;ZHU Yueqi;CHENG Yingsheng(Department of Radiology,Affiliated Shanghai Sixth People′s Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200233,China)

机构地区：[1]上海交通大学医学院附属上海市第六人民医院放射科,上海200233

出　　处：《介入放射学杂志》2024年第12期1367-1372,共6页Journal of Interventional Radiology

基　　金：国家自然科学基金资助项目(81971714)。

摘　　要：食管支架植入是临床应用最广泛的缓解恶性食管梗阻的治疗方法。在多项生物技术进步的推动下,食管支架的应用在过去几年中经历了巨大的变化,因此深入了解各类食管支架的机械性能和材料特性是至关重要的。越来越多的临床证据表明,食管支架拥有卓越的原位药物靶向递送能力,特别是^(125)I放射性食管支架,让医师能够选择更加适合患者情况的个体化诊疗方案,显著提升了治疗的精准性。该文系统性地阐述了不同食管支架各自的优势、面临的最大问题以及癌症治疗方面的最新进展,涵盖实验和临床研究,旨在详细介绍各类食管支架设计思路及作用原理,讨论覆膜、载药等支架表面改性技术的发展前景,并对其缓解食管恶性梗阻的有效性和安全性做出判别。Esophageal stent implantation is the most commonly used clinical treatment for malignant esophageal obstruction.Driven by several biotechnological advances,great progress has been made in the clinical application of esophageal stents in the past few years.Therefore,it is extremely important for interventional physicians to have a thorough understanding of the mechanical properties and material properties of various esophageal stents.More and more clinical evidences indicate that esophageal stents,especially^(125)I radioactive esophageal stent,possess exceptional targeted drug delivery capabilities,which enables the physicians to formulated an individualized diagnosis and treatment plan that is more suitable for the patient′s situation,so as to significantly improve the therapeutic accuracy.This review aims to systematically introduce the respective advantages of different esophageal stents,to discuss the biggest problems faced in the current clinical work,and to summarize the latest advances in cancer treatment,including the fields of both basic experimental study and clinical research.This review also explicates the design ideas and working principles of various esophageal stents in detail,discusses the development prospect of stent surface modification technology such as covered stents and drug-eluting stents,and makes judgment of the effectiveness and safety of these types of stents in alleviating malignant esophageal obstruction.

关 键 词：食管支架 食管癌 介入治疗 经口食管支架植入术 

分 类 号：R735.1[医药卫生—肿瘤]