银杏叶提取物注射液联合阿替普酶静脉溶栓治疗对急性脑梗死患者血小板指标及神经功能的影响  

Effects of Ginkgo Biloba Leaf Extract Injection Combined with Alteplase Intravenous Thrombolytic Therapy on Platelet Indicators and Nerve Function in Patients with Acute Cerebral Infarction

作　　者：侯晓彦 HOU Xiaoyan(Department of Encephalopathy,Heze Traditional Chinese Medicine Hospital,Heze 274000,China)

机构地区：[1]菏泽市中医医院脑病科,山东菏泽274000

出　　处：《反射疗法与康复医学》2024年第20期106-108,124,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨银杏叶提取物注射液联合阿替普酶静脉溶栓治疗对急性脑梗死(ACI)患者的影响。方法回顾性分析菏泽市中医医院2021年1月—2024年1月收治的60例ACI患者的临床资料,按照治疗方法的不同将其分为对照组与观察组,每组30例。对照组采用阿替普酶静脉溶栓治疗,观察组采用银杏叶提取物注射液联合阿替普酶静脉溶栓治疗,两组均连续治疗14 d。对比两组患者的临床疗效、血小板指标、神经功能、日常生活活动能力及不良反应发生情况。结果观察组治疗总有效率为93.33%,高于对照组的66.67%,差异有统计学意义(P<0.05)。治疗后,观察组血小板压积为(0.39±0.08)%,高于对照组的(0.26±0.06)%,血小板平均分布宽度为(10.02±1.03)fl、血小板聚集率为(33.06±2.39)%、血小板粘附率为(25.06±2.17)%,均低于对照组的(12.98±1.84)fl、(36.85±3.14)%、(29.64±2.32)%,组间差异有统计学意义(P<0.05);观察组美国国立卫生研究院卒中量表评分为(6.31±0.87)分,低于对照组的(9.09±1.05)分,Barthel指数评分为(79.88±4.11)分,高于对照组的(70.16±3.25)分,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在ACI患者中,采用银杏叶提取物注射液联合阿替普酶静脉溶栓治疗可改善ACI患者的血小板指标与神经功能,提高日常生活能力,且安全可靠。Objective To investigate the effect of ginkgo biloba leaf extract injection combined with alteplase intravenous thrombolytic therapy on patients with acute cerebral infarction(ACI).Methods A retrospective analysis was conducted on the clinical data of 60 patients with ACI who were admitted to Heze Traditional Chinese Medicine Hospital from January 2021 to January 2024,and were divided into a control group and an observation group according to different treatment methods,with 30 cases in each group.Control group was treated with alteplase intravenous thrombolytic therapy,observation group was treated with ginkgo biloba leaf extract injection combined with alteplase intravenous thrombolytic therapy,both groups were treated for 14 days.The clinical efficacy,platelet indicators,nerve function,activity of daily living and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.33%,which was higher than 66.67%of the control group,and the difference was statistically significant(P<0.05).After treatment,the platelet pressure of observation group was(0.39±0.08)%,which was higher than(0.26±0.06)%of the control group,the average platelet distribution width was(10.02±1.03)fl,the platelet aggregation rate was(33.06±2.39)%,and the platelet adhesion rate was(25.06±2.17)%,they were lower than(12.98±1.84)fl,(36.85±3.14)%and(29.64±2.32)%of the control group,and the differences between groups were statistically significant(P<0.05);the National Institutes of Health Stroke Scale score of the observation group was(6.31±0.87)points,which was lower than(9.09±1.05)points of the control group,and the Barthel index score was(79.88±4.11)points,which was higher than(70.16±3.25)points of the control group,and the differences between the groups were statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In ACI patients,the combination of ginkgo biloba leaf extrac

关 键 词：急性脑梗死 银杏叶提取物注射液 阿普替酶 静脉溶栓 血小板指标 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]