舒肝宁联合异甘草酸镁治疗急性肝炎的临床疗效研究  

Study on clinical efficacy of Shuganning combined with magnesium isoglycyrrhizinate in the treatment of acute hepatitis

作　　者：沈运秋 肖丹 金洁 SHEN Yun-qiu;XIAO Dan;JIN Jie(Department of Gastroenterology,The Fifth People's Hospital,Suzhou 215000,China)

机构地区：[1]苏州市第五人民医院消化内科,215000 [2]苏州市第五人民医院感染科,215000

出　　处：《中国实用医药》2025年第1期6-10,共5页China Practical Medicine

摘　　要：目的分析舒肝宁联合异甘草酸镁治疗急性肝炎的临床效果。方法选取急性肝炎患者90例,随机分成对照组和观察组,各45例。对照组给予异甘草酸镁治疗,观察组给予舒肝宁联合异甘草酸镁治疗。对比两组治疗效果,治疗前后肝功能指标、应激指标、炎症指标及生活质量评分。结果观察组治疗总有效率97.78%高于对照组的84.44%(P<0.05)。治疗后,观察组天门冬氨酸氨基转移酶(AST)(42.69±2.33)U/L、总胆红素(TBil)(20.52±1.01)μmol/L、谷丙转氨酶(ALT)(40.15±2.18)U/L均低于对照组的(49.26±8.15)U/L、(25.15±3.26)μmol/L、(46.26±5.26)U/L(P<0.05)。治疗后,观察组白细胞介素-6(IL-6)(60.26±2.40)pg/ml、C反应蛋白(CRP)(8.36±0.96)mg/L、肿瘤坏死因子-α(TNF-α)(7.22±0.63)pg/ml均低于对照组的(69.26±7.15)pg/ml、(12.52±2.12)mg/L、(10.26±1.26)pg/ml(P<0.05)。治疗后,观察组超氧化物歧化酶(SOD)(92.45±2.63)U/ml高于对照组的(82.56±7.88)U/ml,丙二醛(MDA)(3.05±0.25)μmol/L低于对照组的(4.26±0.65)μmol/L(P<0.05)。治疗后,观察组活力状况、生理职能、情感职能、社会功能评分分别为(72.58±3.15)、(73.85±3.36)、(75.47±3.54)、(74.84±3.20)分,均高于对照组的(61.47±8.62)、(60.78±8.15)、(62.95±8.85)、(63.36±8.41)分(P<0.05)。结论对急性肝炎患者采取舒肝宁与异甘草酸镁治疗的效果较好,可改善肝功能与炎症指标,也能显著缓解氧化应激水平,效果较好,用药后患者的生活质量也能得到一定提升。Objective To analyze the clinical effect of Shuganning combined with magnesium isoglycyrrhizinate in the treatment of acute hepatitis.Methods 90 patients with acute hepatitis were selected and randomly divided into control group and observation group,with 45 cases in each group.The control group was treated with magnesium isoglycyrrhizinate,and the observation group was treated with Shuganning combined with magnesium isoglycyrrhizinate.The therapeutic effect,liver function index,stress index,inflammation index and quality of life score before and after treatment were compared between the two groups.Results The total effective rate of 97.78%in the observation group was higher than 84.44%in the control group(P<0.05).After treatment,the observation group had an aspartate transaminase(AST)of(42.69±2.33)U/L,a total bilirubin(TBil)of(20.52±1.01)μmol/L,and an alanine aminotrasferase(ALT)of(40.15±2.18)U/L,which were lower than(49.26±8.15)U/L,(25.15±3.26)μmol/L,and(46.26±5.26)U/L in the control group(P<0.05).After treatment,the observation group had an interleukin-6(IL-6)of(60.26±2.40)pg/ml,a C-reactive protein(CRP)of(8.36±0.96)mg/L,and a tumor necrosis factor-α(TNF-α)of(7.22±0.63)pg/ml,which were lower than(69.26±7.15)pg/ml,(12.52±2.12)mg/L,and(10.26±1.26)pg/ml in the control group(P<0.05).After treatment,the superoxide dismutase(SOD)of(92.45±2.63)U/ml in the observation group was higher than(82.56±7.88)U/ml in the control group,and the malondialdehyde(MDA)of(3.05±0.25)μmol/L was lower than(4.26±0.65)μmol/L in the control group(P<0.05).After treatment,the scores of vitality,role-physical function,role-emotional and social function in the observation group were(72.58±3.15),(73.85±3.36),(75.47±3.54)and(74.84±3.20)points,which were higher than(61.47±8.62),(60.78±8.15),(62.95±8.85)and(63.36±8.41)points in the control group(P<0.05).Conclusion Shuganning and magnesium isoglycyrrhizinate is effective on patients with acute hepatitis,which can not only improve liver function and inflammation indicat

关 键 词：舒肝宁 异甘草酸镁 急性肝炎 临床疗效 肝功能 

分 类 号：R575.1[医药卫生—消化系统]