利那洛肽联合PEG在慢性便秘患者结肠镜检查肠道准备中效果评价  

Evaluation of the efficacy of linaclotide combined with PEG in the bowel preparation for colonoscopy of patients with chronic constipation

作　　者：高小毛[1] 刘亚文 徐琦德 韩奕 吴作艳[1] GAO Xiaomao;LIU Yawen;XU Qide;HAN Yi;WU Zuoyan(Department of Gastroenterology,Beijing No.6 Hospital,Beijing 100007,China)

机构地区：[1]北京市第六医院消化科,北京100007

出　　处：《中国现代医生》2025年第2期80-83,共4页China Modern Doctor

摘　　要：目的探讨利那洛肽联合复方聚乙二醇电解质散(polyethylene glycol electrolyte powder,PEG)在慢性便秘患者结肠镜检查肠道准备中的的应用效果。方法选取2023年1月至10月在北京市第六医院接受肠镜检查的190例慢性便秘患者作为研究对象,采用随机数字表法分为利那洛肽组(n=63)、3L PEG组(n=64)和4L PEG组(n=63)。比较三组患者的肠道准备效果。结果利那洛肽组患者的Boston肠道准备量表评分高于3L PEG组和4L PEG组,组间比较差异有统计学意义(P<0.05)。利那洛肽组患者的清肠合格率优于3L PEG组与4L PEG组,4L PEG组患者的清肠合格率优于3L PEG组,差异有统计学意义(P<0.05)。结论利那洛肽联合PEG可提高慢性便秘患者的结肠镜检查肠道准备质量,且不增加肠道准备时的不良反应。Objective To explore the application of linaclotide combined with compound polyethylene glycol electrolyte powder(PEG)in bowel preparation for colonoscopy of patients with chronic constipation.Methods A toltal of 190 patients with chronic constipation who underwent electronic colonoscopy in Beijing NO.6 Hospital from January to October 2023 were selected as the objects.The patients were divide into linaclotide group(n=63),3L PEG group(n=64),and 4L PEG group(n=63)by random number table method.The application effects of three groups were compared.Results Boston bowel preparation scale score was higher than 3L PEG and 4L PEG groups,there were significant difference among groups(P<0.05).The qualified rate of patients in linaclotide group was better than that of 3L PEG group and 4L PEG group,and the qualified rate of patients in 4L PEG group was better than that of 3L PEG group,there were significant difference among groups(P<0.05).Conclusion Linaclotide combined with PEG can not only improve the intestinal cleaning quality of patients with constipation,but also do not increase the adverse reactions of patients.

关 键 词：复方聚乙二醇电解质散 利那洛肽 结肠镜检查 肠道准备 

分 类 号：R574.4[医药卫生—消化系统]