入院时血清NLRP3、HMG-1、IL-10水平联合检测对脓毒症患者预后的预测价值  

Predictive value of combined detection of serum NLRP3,HMG-1 and IL-10 levels on hospitalization in patients with sepsis

作　　者：谢彩梨 吴金海[1] 赵菊馨 Xie Cai-li;Wu Jin-hai;Zhao Ju-xin(Department of Emergency,Nanyang First People's Hospital,Nanyang 473000,Henan China)

机构地区：[1]南阳市第一人民医院急诊科,河南南阳473000

出　　处：《四川生理科学杂志》2025年第1期26-29,共4页

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20210972)。

摘　　要：目的:探讨入院时血清Nod样蛋白受体蛋白3(NLRP3)、高迁移率族蛋白1(HMG-1)、白细胞介素-10(IL-10)水平与脓毒症患者病情严重程度的相关性及其联合检测对患者预后的预测价值。方法:选取2022年5月-2023年12月我院收治的110例脓毒症患者,根据病情严重程度分为轻度脓毒症组、严重脓毒症组、脓毒症休克组。比较3组入院时血清NLRP3、HMG-1、IL-10水平及APACHEⅡ评分、SOFA评分;分析入院时血清NLRP3、HMG-1、IL-10水平与APACHEⅡ、SOFA评分相关性;比较不同预后脓毒症患者入院时血清NLRP3、HMG-1、IL-10水平;分析入院时血清NLRP3、HMG-1、IL-10水平联合检测对脓毒症患者预后的预测价值;结果:入院时3组血清NLRP3、HMG-1、IL-10水平及APACHEⅡ、SOFA评分水平比较:轻度脓毒症组<严重脓毒症组<脓毒症休克组,组间两两比较,差异显著(P<0.05);入院时血清NLRP3、HMG-1、IL-10水平与APACHEⅡ、SOFA评分呈正相关(P<0.05);病死脓毒症患者入院时血清NLRP3、HMG-1、IL-10高于生存患者(P<0.05);入院时血清NLRP3、HMG-1、IL-10水平联合检测预测脓毒症患者病死的曲线下面积(AUC)为0.928,高于上述指标的单独检测。结论:入院时血清NLRP3、HMG-1、IL-10水平与脓毒症患者病情严重程度密切相关,且其早期联合检测对脓毒症患者预后具有较高的预测价值,可作为临床预测脓毒症患者预后的血清学指标。Objective:To investigate the correlation of serum NOD-like protein receptor protein 3(NLRP3),high mobility group protein 1(HMG-1)and interleukin-10(IL-10)levels with the severity of sepsis and the predictive value of combined detection on the prognosis of sepsis patients.Methods:A total of 110 patients with sepsis admitted to our hospital from May 2022 to December 2023 were selected and divided into mild sepsis group,severe sepsis group and septic shock group according to the severity of the disease.The serum NLRP3,HMG-1,IL-10 levels,APACHEⅡscore and SOFA score were compared among 3 groups at admission.The correlation of serum NLRP3,HMG-1,IL-10 levels with APACHEⅡand SOFA scores at admission was analyzed;the serum NLRP3,HMG-1 and IL-10 levels were compared in sepsis patients with different prognosis.The predictive value of combined detection of serum NLRP3,HMG-1 and IL-10 levels in sepsis patients at admission was analyzed.Results:The serum NLRP3,HMG-1,IL-10 levels and APACHEⅡand SOFA scores were compared among the 3 groups at admission:mild sepsis group<severe sepsis group<septic shock group,the difference was significant(P<0.05);Serum NLRP3,HMG-1 and IL-10 levels were positively correlated with APACHEⅡand SOFA scores at admission(P<0.05).Serum NLRP3,HMG-1 and IL-10 levels in sepsis patients were higher than those in survival patients(P<0.05).The area under the curve(AUC)of serum NLRP3,HMG-1 and IL-10 levels combined detection at admission for predicting sepsis patients was 0.928,which was higher than that of the single detection of the above indicators.Conclusion:Serum NLRP3,HMG-1 and IL-10 levels at admission are closely related to the severity of sepsis,and their early combined detection has a high predictive value for the prognosis of sepsis patients,and can be used as serological indexes to predict the prognosis of sepsis patients.

关 键 词：脓毒症 血清Nod样蛋白受体蛋白3 高迁移率族蛋白1 白细胞介素-10 

分 类 号：R73[医药卫生—肿瘤]