丁苯酚辅助尤瑞克林对大动脉粥样硬化型脑卒中患者脑血管储备功能及氧化应激指标的影响  

Influence of butylphenol supplemented with urinary kallidinogenase on cerebrovascular reserve function and oxidative stress indicators in patients with large-artery atherosclerotic stroke

作　　者：潘德雾 黄晶 Pan De-wu;Huang Jing(Department of Neurology,Dayu People’s Hospital,Ganzhou 341500,Jiangxi,China;Department of Neurosurgery,Dayu People’s Hospital,Ganzhou 341500,Jiangxi,China)

机构地区：[1]大余县人民医院神经内科,江西赣州341500 [2]大余县人民医院神经外科,江西赣州341500

出　　处：《四川生理科学杂志》2025年第1期77-79,188,共4页

摘　　要：目的:探究丁苯酚辅助尤瑞克林对大动脉粥样硬化型脑卒中患者脑血管储备功能及氧化应激指标的影响。方法:选取2022年1月至2024年1月期间收治的60例大动脉粥样硬化型脑卒中患者,采用随机掷硬币法将患者随机分为各30例的常规组(给予常规药物治疗加上尤瑞克林治疗)和联合组(在常规组基础上加上丁苯酚治疗)。在患者治疗前和治疗3 w w后比较两组的神经功能(美国国立卫生研究院卒中量表评分)、血管储备能力(搏动指数值、储备功能值、屏气指数)及氧化应激指标水平(血清丙二醛水平、超氧化物歧化酶水平)。结果:用药结束后,联合组患者卒中量表评分、搏动指数值、血清丙二醛水平均低于常规组,储备功能值、屏气指数和超氧化物歧化酶水平高于常规组(P均<0.05);两组用药后不良情况差异无统计学意义(P>0.05)。结论:丁苯酚辅助尤瑞克林能够明显改善大动脉粥样硬化型脑卒中患者的神经功能、脑血管储备功能及氧化应激指标水平,且具备安全性。Objective:To explore the influence of butylphenol supplemented with urinary kallidinogenase on cerebrovascular reserve function and oxidative stress indicators in patients with large-artery atherosclerotic stroke.Methods:Sixty patients with large-artery atherosclerotic stroke admitted from January 2022 to January 2024 were selected and randomly divided into conventional group(30 cases,conventional drug therapy plus urinary kallidinogenase treatment)and combined group(30 cases,butylphenol treatment based on conventional group)by random coin tossing method.The neurological function(National Institutes of Health Stroke Scale score),vascular reserve capacity(pulsatility index,cerebrovascular reserve value,breath holding index)and oxidative stress indicators(serum malondialdehyde level,superoxide dismutase level)were compared between groups before treatment and after 3 weeks of treatment.Results:After the end of medication,the National Institutes of Health Stroke Scale score,pulsatility index value and serum malondialdehyde level in combined group were lower than those in conventional group while the cerebrovascular reserve value,breath holding index value and superoxide dismutase level were higher than those in conventional group(all P<0.05).There were no statistical differences in adverse conditions between groups after medication(P>0.05).Conclusion:Butylphenol supplemented with urinary kallidinogenase can significantly improve the neurological function,cerebrovascular reserve function and oxidative stress indicators of patients with large-artery atherosclerotic stroke,and it has safety.

关 键 词：丁苯酚 尤瑞克林 大动脉粥样硬化型脑卒中 血管储备功能 氧化应激 

分 类 号：R74[医药卫生—神经病学与精神病学]