同型半胱氨酸、D-二聚体在脑梗死患者中的表达及意义探究  

Expression and significance of homocysteine and D-dimer in patients with cerebral infarction

作　　者：张红梅 Zhang Hong-mei(Department of Clinical Laboratory,Liangyuan Hospital of Traditional Chinese Medicine,Shangqiu 476000,Henan,China)

机构地区：[1]商丘市梁园区中医医院检验科,河南商丘476000

出　　处：《四川生理科学杂志》2025年第1期193-195,共3页

摘　　要：目的:分析血清同型半胱氨酸(Homocysteine,Hcy)、D-二聚体(D-dimer,D-D)指标在脑梗死患者中的表达及临床意义。方法:回顾性收集2020年1月至2023年8月期间本院收治的65例脑梗死患者的临床资料,纳入观察组。同时纳入同期本院收治的非脑梗死患者65例作为对照组。分析比较两组的血清Hcy、D-D水平。根据美国国立卫生研究院卒中量表评分将观察组分为轻型组、中型组、重型组,比较三组患者血清Hcy、D-D水平;统计患者预后情况,并绘制受试者工作曲线(Receiver operating characteristic,ROC)分析血清Hcy、D-D对预后的预测价值。结果:65例脑梗死患者中31例预后不良,34例预后良好。观察组血清Hcy、D-D水平均显著高于对照组(P<0.05)。不同神经缺损程度患者的血清Hcy、D-D水平有显著差异(P<0.05)。预后不良组血清Hcy、D-D水平均显著高于对照组(P<0.05)。绘制ROC曲线,血清Hcy、D-D及联合预测预后的曲线下面积(Area under curve,AUC)均>0.70,有一定的预测价值,且联合预测价值更高。结论:血清Hcy、D-D在脑梗死患者中呈高水平表达,神经缺损程度越重,血清Hcy、D-D越高,且可预测患者预后情况。Objective:To analyze the expression and clinical significance of serum homocysteine(Homocysteine,Hcy)and D-dimer(D-dimer,D-D)in patients with cerebral infarction.Methods:The clinical data of 65 patients with cerebral infarction admitted to our hospital from January 2020 to August 2023 were retrospectively collected and included into the observation group.Meanwhile,65 patients with non-cerebral infarction admitted to our hospital during the same period were included as the control group.The serum Hcy and D-D levels of the two groups were analyzed and compared.According to the National Institutes of Health Stroke Scale score,the observation group was divided into light group,medium group and severe group,and the serum Hcy and D-D levels of the three groups were compared.The prognosis of patients was counted,and ROC(Receiver operating characteristic)curve was drawn to analyze the predictive value of serum Hcy and D-D for prognosis.Results:Among 65 patients with cerebral infarction,31 cases had poor prognosis and 34 cases had good prognosis.Serum Hcy and D-D levels in observation group were significantly higher than those in control group(P<0.05).There were significant differences in serum Hcy and D-D levels in patients with different degree of nerve defect(P<0.05).Serum Hcy and D-D levels in poor prognosis group were significantly higher than those in control group(P<0.05).According to ROC curve,serum Hcy,D-D and AUC(Area under curve)of combined prediction were all>0.70,which had certain predictive value,and the combined prediction value was higher.Conclusion:Serum Hcy and D-D are highly expressed in patients with cerebral infarction,and the higher the degree of nerve defect,the higher the serum Hcy and D-D,and can predict the prognosis of patients.

关 键 词：脑梗死 血清同型半胱氨酸 血清D-二聚体 神经缺损程度 预后 

分 类 号：R74[医药卫生—神经病学与精神病学]