Prevalence of potential drug‒drug interactions and associated factors among elderly patients in Ethiopia:a systematic review and meta-analysis  

作　　者：Tekletsadik Tekleslassie Alemayehu Yilkal Abebaw Wassie Abaynesh Fentahun Bekalu Addisu Afrassa Tegegne Wondim Ayenew Gebresilassie Tadesse Demis Getachew Abebaw Setegn Yazie Bisrat Birke Teketelew Mekonnen Derese Mekete Setegn Fentahun Tesfaye Birhanu Abebe Tefera Minwagaw Gebremariam Wulie Geremew 

机构地区：[1]Department of Social and Administrative Pharmacy,School of Pharmacy,College of Medicine and Health Sciences,University of Gondar,Gondar,Ethiopia. [2]Department of Clinical Pharmacy,School of Pharmacy,College of Medicine and Health Sciences,University of Gondar,Gondar,Ethiopia [3]Department of Pharmacology,School of Pharmacy,College of Medicine and Health Sciences,University of Gondar,Gondar,Ethiopia [4]Department of Pharmaceutical Chemistry,School of Pharmacy,College of Medicine and Health Sciences,University of Gondar,Gondar,Ethiopia [5]Department of Medical Nursing,School of Nursing,College of Medicine and Health Sciences,University of Gondar,Gondar,Ethiopia [6]Department of Hematology and Immune Hematology,School of Laboratory,College of Medicine and Health Sciences,University of Gondar,Gondar,Ethiopia [7]Department of Psychiatry,School of Medicine,College of Medicine and Health Sciences,University of Gondar,Gondar,Ethiopia [8]Department of Internal Medicine,School of Medicines College of Medicine and Health Sciences,University of Gondar,Gondar,Ethiopia [9]Department of Medical Parasitology,School of Biomedical and Laboratory Sciences College of Medicine and Health Sciences,University of Gondar,Gondar,Ethiopia [10]Department of Pharmacy,Bahir Dar University,Bahir Dar,Ethiopia [11]Department of Pharmacy,Debremarkos University,Debremarkos,Ethiopia

出　　处：《Global Health Research and Policy》2024年第1期82-94,共13页全球健康研究与政策(英文)

摘　　要：Background The occurrence of potential drug‒drug interactions(pDDIs)is a serious global issue that affects all age groups,with the elderly population being the most vulnerable.This is due to their relatively high rates of comorbid-ity and polypharmacy,as well as physiological changes that can increase the potential for DDIs and the likelihood of adverse drug reactions.The aim of this study was to estimate the prevalence of pDDIs and associated factors among elderly patients in Ethiopia.Methods A comprehensive literature search using the preferred reporting items for systematic review and meta-analysis statement was conducted on HINARI,Science Direct,Embase,PubMed/MEDLINE,Google Scholar,and Research Gate.Data were extracted via a Microsoft Excel spreadsheet and analyzed via STATA version 11.0.Egger regression tests and funnel plot analysis were used to check publication bias,and theI2 statistic was used to evalu-ate statistical heterogeneity.Sensitivity and subgroup analyses were also conducted to identify potential causes of heterogeneity.Results Seven articles were analyzed,and a total of 1897 pDDIs were identified in 970 patients,resulting in an aver-age of 1.97 DDIs per patient.The number of DDIs per patient ranged from 0.18 to 5.86.The overall prevalence of pDDIs among elderly patients was 50.69%(95%CI 18.77–82.63%).However,the prevalence of pDDIs ranged widely from 2.80 to 90.1%.When the severity of the interactions was considered,the prevalence of potential DDIs was found to be 28.74%,70.68%,and 34.20%for major,moderate,and minor pDDIs,respectively.Polypharmacy and long hospi-tal stays were identified as factors associated with pDDIs among elderly patients in Ethiopia.Conclusions The overall prevalence of pDDIs among elderly patients was high,with a wide range of prevalence rates.Moderate-severity interactions were the most prevalent.Polypharmacy and long hospital stays were identified as factors associated with pDDIs among elderly patients.The study suggests that DDIs identification database itself cou

关 键 词：PREVALENCE Potential drug‒drug interaction Associated factors ELDERLY Ethiopia 

分 类 号：R73[医药卫生—肿瘤]