Celiac artery mesenteric fat measurement with endosonography(CAMEUS)reliably correlates with obesity and related comorbidities  

作　　者：Fateh Bazerbachi Serge Baroud Michael J.Levy Daniel B.Maselli Eric J.Vargas Aliana Bofill-Garcia Ryan J.Law Vinay Chandrasekhara Andrew C.Storm Ferga C.Gleeson Elizabeth Rajan Prasad G.Iyer Kymberly D.Watt Barham K.Abu Dayyeh 

机构地区：[1]CentraCare,Interventional Endoscopy Program,St Cloud Hospital,St.Cloud,MN,USA [2]Division of Gastroenterology,Hepatology and Nutrition,University of Minnesota,Minneapolis,MN,USA [3]Department of Internal Medicine,MetroHealth Medical Center and Case Western Reserve University,Cleveland,OH,USA [4]Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN,USA

出　　处：《Gastroenterology Report》2024年第1期191-197,共7页胃肠病学报道(英文)

摘　　要：Background:Visceral fat represents a metabolically active entity linked to adverse metabolic sequelae of obesity.We aimed to determine if celiac artery mesenteric fat thickness can be reliably measured during endoscopic ultrasound(EUS),and if these measurements correlate with metabolic disease burden.Methods:This was a retrospective analysis of patients who underwent celiac artery mesenteric fat measurement with endosonography(CAMEUS)measurement at a tertiary referral center,and a validation prospective trial of patients with obesity and nonalcoholic steatohepatitis who received paired EUS exams with CAMEUS measurement before and after six months of treatment with an intragastric balloon.Results:CAMEUS was measured in 154 patients[56.5%females,mean age 56.5±18.0years,body mass index(BMI)29.8±8.0 kg/m^(2)]and was estimated at 14.7±6.5mm.CAMEUS better correlated with the presence of non-alcoholic fatty liver disease(NAFLD)(R^(2)=0.248,P<0.001)than BMI(R^(2)=0.153,P<0.001),and significantly correlated with metabolic parameters and diseases.After six months of intragastric balloon placement,the prospective cohort experienced 11.7%total body weight loss,1.3 points improvement in hemoglobin A1c(P=0.001),and a 29.4%average decrease in CAMEUS(−6.4±5.2mm,P<0.001).CAMEUS correlated with improvements in weight(R^(2)=0.368),aspartate aminotransferase to platelet ratio index(R^(2)=0.138),and NAFLD activity score(R^(2)=0.156)(all P<0.05).Conclusions:CAMEUS is a novel measure that is significantly correlated with critical metabolic indices and can be easily captured during routine EUS to risk-stratify susceptible patients.This station could allow for EUS access to sampling and therapeutics of this metabolic region.

关 键 词：endoscopic ultrasonography upper endoscopy nonalcoholic fatty liver disease OBESITY metabolic syndrome 

分 类 号：R589.2[医药卫生—内分泌]