Association between mucosectomy and endoscopic outcomes in patients with ileal pouch-anal anastomosis  

作　　者：Amy Hembree Bo Shen Daniel Freedberg 

机构地区：[1]Division of Digestive and Liver Diseases,Department of Medicine,Columbia University Irving Medical Center,New York-Presbyterian Hospital,New York,NY,USA

出　　处：《Gastroenterology Report》2024年第1期317-324,共8页胃肠病学报道(英文)

摘　　要：Background:In patients with inflammatory bowel disease(IBD)for whom medical therapy is unsuccessful or who develop colitis-as-sociated neoplasia,restorative proctocolectomy with ileal pouch-anal anastomosis(IPAA)is often indicated.One consideration for surgeons performing this procedure is whether to create this anastomosis using a stapled technique without mucosectomy or using a hand-sewn technique with mucosectomy.This study tested the association between IPAA anastomosis technique and cuffitis and/or pouchitis,assessed endoscopically.Methods:This was a retrospective cohort study.We included consecutive adult patients with IBD who had undergone IPAA and had received index pouchoscopies at Columbia University Irving Medical Center between 2020 and 2022.Patients were then followed up from this index pouchoscopy for≤12 months to a subsequent pouchoscopy.The primary exposure was mucosectomy vs non-mucosectomy and the primary outcome was cuffitis and/or pouchitis,defined as a Pouch Disease Activity Index endoscopy subscore of≥1.Results:There were 76 patients who met study criteria including 49(64%)who had undergone mucosectomy and 27(36%)who had not.Rates of cuffitis and/or pouchitis were 49%among those with mucosectomy vs 41%among those without mucosectomy(P=0.49).Time-to-event analysis affirmed these findings(log-rank P=0.77).Stricture formation was more likely among patients with mucosectomy compared with those without mucosectomy(45%vs 19%,P=0.02).Conclusions:There was no association between anastomosis technique and cuffitis and/or pouchitis among patients with IBD.These results may support the selection of stapled anastomosis over hand-sewn anastomosis with mucosectomy.

关 键 词：ileal pouch-anal anastomosis IPAA POUCHITIS cuffitis inflammatory bowel disease IBD 

分 类 号：R57[医药卫生—消化系统]