Supplementation with probiotics,prebiotics,and synbiotics in patients with chronic functional constipation:a randomized,double-blind,placebo-controlled pilot clinical trial  

作　　者：Ana Terrén Lora Bruno F.Penadés Sara López Oliva Sari Arponen Gülsah Okutan Guerthy Melissa Sánchez Niño Ismael San Mauro Martín 

机构地区：[1]Research Centers in Nutrition and Health(CINUSA Group),Research Department,Madrid,Spain [2]Slow Medicine Institute,Research Department,Alcobendas,Madrid,Spain

出　　处：《Gastroenterology Report》2024年第1期458-466,共9页胃肠病学报道(英文)

摘　　要：Background:Functional constipation includes a set of gastrointestinal symptoms unexplainable by an identifiable underlying physical cause or pathology.The prevalence of this condition is high and there is a need to develop strategies to reduce it.Probiotics,prebiotics,and synbiotics may be an alternative treatment for chronic functional constipation.Methods:To compare the efficacy of dietary supplementation on symptoms of patients who suffer from chronic functional constipation.An exploratory,randomized,double-blind,placebo-controlled pilot clinical trial was conducted with 74 patients diagnosed with chronic functional constipation who were divided into four treatment groups-Group A:probiotics;Group B:prebiotics;Group C:synbiotics;Group D:placebo.Each patient was treated for 8weeks.At the beginning and end of treatment,data were collected by administering questionnaires and scales,including the Bristol stool scale,on gastrointestinal symptoms,bowel movements,and sociodemographic and anthropometric characteristics.Results:Stool frequency increased in all four study groups,and greatest difference was observed in the synbiotics group(2.8±1.3 vs.5.9±2.6;P<0.001).Stool consistency improved only in the active treatment groups.Based on the evaluation of gastrointestinal symptoms,participants treated with prebiotics,probiotics and synbiotics showed the greatest improvement in abdominal pain(8.28±2.63 vs.6.56±2.62;P=0.009),gastroesophageal reflux(4.60±2.66 vs.3.45±2.42;P=0.039)and constipation symptoms(13.00±3.97 vs.8.71±3.35;P=0.003),respectively.As for quality of life,the main changes were observed in physical health domains,with a placebo effect.Conclusions:The present study provides evidence supporting the efficacy of dietary supplementation with probiotics,prebiotics,and synbiotics in patients with chronic functional constipation after 8weeks of treatment.

关 键 词：functional constipation PROBIOTICS PREBIOTICS gastrointestinal symptoms stool frequency stool consistency 

分 类 号：R57[医药卫生—消化系统]