Noninvasive tests for liver fibrosis in 2024:are there different scales for different diseases?  

作　　者：Jimmy Che-To Lai Lilian Yan Liang Grace Lai-Hung Wong 

机构地区：[1]Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong SAR,China [2]State Key Laboratory of Digestive Disease,The Chinese University of Hong Kong,Hong Kong SAR,China [3]Medical Data Analytics Centre,The Chinese University of Hong Kong,Hong Kong SAR,China

出　　处：《Gastroenterology Report》2024年第1期499-513,共15页胃肠病学报道(英文)

基　　金：supported by the General Research Fund-Research Grant Council(Project reference number:14106922)grant to Grace Wong.

摘　　要：Liver fibrosis is the common pathway from various chronic liver diseases and its progression leads to cirrhosis which carries a significant risk for the development of portal hypertension-related complications and hepatocellular carcinoma.It is crucial to identify and halt the worsening of liver fibrosis given its important prognostic implication.Liver biopsy is the gold standard for assessing the degree of liver fibrosis but is limited due to its invasiveness and impracticality for serial monitoring.Many noninvasive tests have been developed over the years trying to assess liver fibrosis in a practical and accurate way.The tests are mainly laboratory-or imaging-based,or in combination.Laboratory-based tests can be derived from simply routine blood tests to patented laboratory parameters.Imaging modalities include ultrasound and magnetic resonance elastography,in which vibration-controlled transient elastography is the most widely validated and adopted whereas magnetic resonance elastography has been proven the most accurate liver fibrosis assessment tool.Nonetheless,noninvasive tests do not always apply to all liver diseases,nor does a common cut-off value of a test mean the same degree of liver fibrosis in different scenarios.In this review,we discuss the diagnostic and prognostic performance,as well as the confounders and limitations,of different noninvasive tests on liver fibrosis assessment in various liver diseases.

关 键 词：FIB-4 liver fibrosis liver stiffness measurement noninvasive test vibration-controlled transient elastography 

分 类 号：R57[医药卫生—消化系统]