Starvation hepatitis and refeeding-induced hepatitis:mechanism,diagnosis,and treatment  

作　　者：Marco Biolato Rosy Terranova Caterina Policola Alfredo Pontecorvi Antonio Gasbarrini Antonio Grieco 

机构地区：[1]Department of Medical and Surgical Sciences,CEMAD,Fondazione Policlinico Universitario Agostino Gemelli IRCCS,Rome,Italy [2]Department of Translational Medicine and Surgery,Catholic University of Sacred Heart,Rome,Italy [3]Unit of Endocrinology,Fondazione Policlinico Universitario Agostino Gemelli IRCCS,Rome,Italy

出　　处：《Gastroenterology Report》2024年第1期562-567,共6页胃肠病学报道(英文)

基　　金：Thanks to Fondazione Roma for the invaluable support for scientific research-FR-CEMAD 21-25.

摘　　要：Anorexia nervosa(AN)is one of the most common psychiatric disorders among young adults and is associated with a substantial risk of death from suicide and medical complications.Transaminase elevations are common in patients with AN at the time of hospital admission and have been associated with longer lengths of hospital stay.Multiple types of hepatitis may occur in these patients,including two types that occur only in patients with AN:starvation hepatitis and refeeding-induced hepatitis.Starvation hepatitis is characterized by severe transaminase elevation in patients in the advanced phase of protein-energy deprivation and is associated with complications of severe starvation,such as hypoglycaemia,hypothermia,and hypotension.Refeeding-induced hepatitis is characterized by a milder increase in transaminases that occurs in the early refeeding phase and is associated with hypophosphatemia,hypokalemia,and hypomagnesaemia.Among the most common forms of hepatitis,drug-induced liver injury is particularly relevant in this patient cohort,given the frequent use and abuse of methamphetamines,laxatives,antidepressants,and antipsychotics.In this review,we provided an overview of the different forms of anorexic-associated hepatitis,a diagnostic approach that can help the clinician to correctly frame the problem,and indications on their management and treatment.

关 键 词：TRANSAMINASES HEPATITIS refeeding syndrome STARVATION anorexia nervosa fatty liver 

分 类 号：R575.1[医药卫生—消化系统]