Current status of serum metabolites biomarkers for polyps and colorectal cancer:a systematic review  

作　　者：Maryam Fatimah Abu Bakar Azmawati Mohammed Nawi Siok Fong Chin Suzana Makpol 

机构地区：[1]Department of Public Health Medicine,Faculty of Medicine,Universiti Kebangsaan Malaysia,Cheras,Kuala Lumpur,Malaysia [2]UKM Medical Molecular Biology Institute(UMBI),UKM Medical Centre,Cheras,Kuala Lumpur,Malaysia [3]Department of Biochemistry,Faculty of Medicine,Universiti Kebangsaan Malaysia,Cheras,Kuala Lumpur,Malaysia

出　　处：《Gastroenterology Report》2024年第1期762-771,共10页胃肠病学报道(英文)

基　　金：The authors are grateful to the Ministry of Higher Education(MOHE),Malaysia,for the allocation of the Fundamental Research Grant Scheme(FRGS),grant number FRGS/1/2021/SKK05/UKM/02/1.

摘　　要：Background:Early detection of colorectal cancer(CRC)is crucial to enhance the disease treatment and prognosis of patients.Colonoscopy remains the gold standard for CRC detection;however,it requires trained personnel with expensive tools.Currently,serum metabolites have been discovered to be used to discriminate patients with polyps and CRC.This study aimed to identify the most commonly detected predictive serum metabolites for polyps and CRC.Methods:A systematic search of the Web of Science,PubMed,and Cochrane Library databases was conducted using PRISMA guidelines.Ten studies investigating serum metabolite biomarkers of CRC and polyps using different analytical platforms and study populations were included.QUADOMICS tool was used to analyse the quality of the included studies.All reported metabolites were then enriched into the pathways using MetaboAnalyst 5.0.Results:We found that several potential signature metabolites overlapped between studies,including tyrosine,lysine,cystine,arabinose,and lactate for CRC and lactate and glutamate for polyps.The most affected pathways related to CRC were the urea cycle,glutathione metabolism,purine metabolism,glutamate metabolism,and ammonia recycling.In contrast,those affected in the polyps were the urea cycle,glutamate metabolism,glutathione metabolism,arginine and proline metabolism,and carnitine synthesis.Conclusions:This review has found commonly detected serum metabolites for polyps and CRC with huge potential to be used in clinical settings.However,the differences between altered pathways in polyps and CRC,other external factors,and their effects on the regulation level,sensitivity,and specificity of each identified metabolite remained unclear,which could benefit from a further extensive cohort study and well-defined analysis equipment.

关 键 词：serum biomarker metabolomics colorectal carcinoma colorectal adenoma screening tool 

分 类 号：R735.34[医药卫生—肿瘤]