气络学说精气神理论指导早衰防治及研究进展  

Premature Aging Prevention and Treatment Guided by Essence-Qi-Spirit Theory of Qiluo Doctrine:A Review

作　　者：集川原 李红蓉 郝佳梦 王丹东 马玉聪 马坤 魏聪 JI Chuanyuan;LI Hongrong;HAO Jiameng;WANG Dandong;MA Yucong;MA Kun;WEI Cong(Institute of Integrative Medicine,Hebei University of Chinese Medicine,Shijiazhuang 050091,China;Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns,Shijiazhuang 050091,China;National Key Laboratory of Luobing Theory Innovation and Transformation,Shijiazhuang 050035,China;Hebei Yiling Hospital,Shijiazhuang 050091,China;China Science and Technology Development Center for Chinese Medicine,Beijing 100027,China;Xianyang Central Hospital,Xianyang 712000,China;Shijiazhuang New Drug Technology Innovation Center of Compound Traditional Chinese Medicine,Shijiazhuang 050035,China)

机构地区：[1]河北中医药大学中西医结合研究所,石家庄050091 [2]河北省中西医结合肝肾病证研究重点实验室,石家庄050091 [3]络病理论创新转化全国重点实验室,石家庄050035 [4]河北以岭医院,石家庄050091 [5]中国中医药科技发展中心(国家中医药管理局人才交流中心),北京100027 [6]咸阳市中心医院,陕西咸阳712000 [7]石家庄市复方中药新药技术创新中心,石家庄050035

出　　处：《中国实验方剂学杂志》2025年第2期279-285,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点研发计划“中医药现代化”重点专项课题(2023YFC3504300);石家庄市技术创新中心绩效后补助项目(237790639A);河北省省属高校基本科研项目(QNZR2024007);河北中医药大学燕赵医学研究项目(YZZY2023011)。

摘　　要：早衰的理论基础源于《黄帝内经》,病因复杂,病机以虚为主,治法以补为主。气络学说精气神理论概括“精是生命起源,气是生命动力,神是生命体现”的生命规律,提出“肾精虚衰是衰老根本,元气亏虚是衰老关键,形神耗损是衰老表现”的衰老核心病机,“补肾填精、燮理阴阳、温扶元气、充养形神”的治法及抗衰老代表药物。该文从天年、半百而衰、衰、老概念角度展开,解读早衰的源流及内涵,在气络学说精气神理论指导下阐释“肾精早夺、元气亏虚、积虚成损、形神衰损”的早衰病机,总结早衰治法及代表药物现代医学研究进展,发现该药物对整体早衰、系统性功能衰退和相关疾病疗效确切。该研究为解决早衰及老年病问题提供理论依据和新的思路。The theoretical basis of premature aging originates from The Yellow Emperor's Inner Classic.The etiology of premature aging is complex,and the disease mechanism is based on deficiency.The treatment for premature aging is based on tonicity.The essence-Qi-spirit theory of Qiluo doctrine summarizes that"essence is the origin of life,Qi is the driving force of life,and spirit is the embodiment of life",which is the law of life.The theory puts forward the core disease mechanism of aging,which states that"deficiency of kidney essence is the root of aging,deficiency of primordial Qi is the key to aging,impairment of soma and spirit is the manifestation of aging".The theory also proposes the treatment of"tonifying kidney and supplementing essence,harmonizing Yin and Yang,warming and supporting primordial Qi,and nourishing soma and spirit"and the representative antiaging drugs.The article unfolds from the perspective of the concepts of natural life span,premature senility before fifty,decline,and aging and also explains the origins and connotations of premature aging.The article explains the disease mechanism of premature aging under the guidance of the essence-Qi-spirit theory of Qiluo doctrine,which is"early deprivation of kidney essence,deficiency of primordial Qi,accumulation of deficiencies into impairment,and decline and impairment of soma and spirit",summarizes the progress of modern medical research on the treatment of premature aging and representative drugs,and finds that Bazi Bushen capsules have a precise therapeutic effect on the overall premature aging,systematic functional decline,and related diseases.The study provides theoretical basis and new ideas to solve the problems of premature aging and geriatric diseases.

关 键 词：气络学说 精气神理论 早衰 抗衰老 八子补肾胶囊 

分 类 号：R226[医药卫生—中医基础理论] R277[医药卫生—中医学] R242