基于数据挖掘探析陈竞纬教授治疗新型冠状病毒感染后心悸气阴两虚证用药规律  

Analysis of professor CHEN Jingwei's medication rule in the treatment of palpitation with Qi and Yin deficiency syndrome after Corona Virus Disease 2019 based on data mining

作　　者：陆英 陈竞纬[2] LU Ying;CHEN Jingwei(Nanjing University of Chinese Medicine,Nanjing 210023;Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Suzhou 215009,China)

机构地区：[1]南京中医药大学,江苏南京210023 [2]南京中医药大学附属苏州市中医医院,江苏苏州215009

出　　处：《临床医学研究与实践》2025年第4期11-14,共4页Clinical Research and Practice

基　　金：2024年度苏州市“科教强卫”项目(No.ZDXM2024013);苏州市2022年度第二十八批科技发展计划(医疗卫生科技创新)项目(No.SKYD2022038);苏州市2020年度科技发展计划(民生科技-医疗卫生应用基础研究[第四批])项目(No.SYSD2020210)。

摘　　要：目的 基于中医传承辅助平台(V2.5)探究陈竞纬教授治疗新型冠状病毒感染(简称“新冠”)后心悸气阴两虚证的用药规律。方法 收集陈竞纬教授治疗新冠后心悸的门诊病例处方,借助中医传承辅助平台(V2.5),采用频次、性味归经、关联规则、复杂熵层次聚类分析等数据挖掘方法,进行用药规律分析。结果 共收集54例病例,包括54首处方,涉及中药94味,总计694次。使用频次≥10次的药物有18味,排名前10位的依次为五味子、麦冬、太子参、茯神、龙骨、酸枣仁、牡蛎、炒白术、淮小麦、陈皮。中药四气以平、温、寒为主;五味以甘、苦、酸为主;归经多入肝、心、肺经。基于关联规则分析获得高频药物组合12组,排名前3位的依次为麦冬-五味子、太子参-五味子、麦冬-太子参。基于复杂熵层次聚类算法,演化出7个新处方。结论 陈竞纬教授治疗新冠后气阴两虚证心悸以益气养阴、养心安神、镇心定悸、调和阴阳为主。Objective To explore the medication rule of professor CHEN Jingwei in the treatment of palpitation with Qi and Yin deficiency syndrome after Corona Virus Disease 2019(COVID-19)based on the traditional Chinese medicine inheritance auxiliary platform(V2.5).Methods Professor CHEN Jingwei's outpatient prescriptions for the treatment of palpitation after COVID-19 were collected.With the help of the traditional Chinese medicine inheritance auxiliary platform(V2.5),data mining methods such as frequency,taste and meridian,association rules,and complex entropy hierarchical clustering analysis were used to analyze the medication rules.Results A total of 54 cases were collected,including 54 prescriptions,involving 94 flavors of traditional Chinese medicine,a total of 694 times.There were 18 kinds of drugs used more than 10 times,and the top 10 were Schisandrae Chinensis,Ophiopogonis Radix,Pseudostellariae heterophylla,Poria cum Radix Pini,Os Praconis,Ziziphi Spinosae Semen,Ostreae Concha,fried Atractylodes Rhizome,Huai wheat,Citri Reticulatae Pericarpium.The four Qi of traditional Chinese medicine were mainly flat,warm and cold;the five flavors were mainly sweet,bitter and sour;channel tropism mostly enters the liver,heart and lung meridians.Based on association rule analysis,12 groups of high-frequency drug combinations were obtained,and the top three were Ophiopogonis radix-Schisandrae chinensis,Pseudostellariae radix-Schisandrae chinensis,Ophiopogonis radix-Pseudostellariae radix.Based on the complex entropy hierarchical clustering algorithm,7 new prescriptions were evolved.Conclusion Professor CHEN Jingwei's treatment of palpitation with Qi and Yin deficiency syndrome after COVID-19 is mainly based on replenishing Qi and nourishing Yin,nourishing heart and tranquilizing mind,calming heart and calming palpitations,and regulating Yin and Yang.

关 键 词：新型冠状病毒感染 心悸 气阴两虚证 中医传承辅助平台 用药规律 

分 类 号：R22[医药卫生—中医基础理论]