血清CEA、CYFRA21-1及ALP联合检测对NSCLC患者发生骨转移的诊断价值  

Diagnostic value of combined detection of serum CEA,CYFRA21-1 and ALP in bone metastasis of NSCLC patients

作　　者：赵多祥 李伟 彭帆 魏晓婷 祁彦霞 ZHAO Duoxiang;LI Wei;PENG Fan;WEI Xiaoting;QI Yanxia(Baoji High-tech Hospital,Baoji 721000;the People's Hospital of Pengyang,Guyuan 756500,China)

机构地区：[1]宝鸡高新医院,陕西宝鸡721000 [2]彭阳县人民医院,宁夏固原756500

出　　处：《临床医学研究与实践》2025年第4期98-101,共4页Clinical Research and Practice

摘　　要：目的探讨血清癌胚抗原(CEA)、细胞角蛋白19片段抗原21-1(CYFRA21-1)及碱性磷酸酶(ALP)联合检测对非小细胞肺癌(NSCLC)患者发生骨转移的诊断价值。方法选取2020年8月至2022年8月确诊为NSCLC的68例患者作为NSCLC组,再根据发射型计算机断层扫描(ECT)检查结果将其分为骨转移组(n=31)和非骨转移组(n=37)。另将同期确诊为肺部良性病变的32例患者作为良性病变组。分别比较NSCLC组与良性病变组、骨转移组与非骨转移组的血清指标;绘制受试者工作特征(ROC)曲线分析血清指标检测对NSCLC患者发生骨转移的诊断效能;并观察不同数量、不同病理分型骨转移病灶患者的血清指标。结果NSCLC组的CEA、CYFRA21-1及ALP水平高于良性病变组(P<0.05)。骨转移组的CEA、CYFRA21-1及ALP水平高于非骨转移组(P<0.05)。CEA、CYFRA21-1及ALP联合检测诊断NSCLC患者发生骨转移的曲线下面积(AUC)为0.937,均明显高于单一指标检测。骨转移病灶≥3处患者的CEA、CYFRA21-1及ALP水平高于转移病灶<3处患者(P<0.05)。结论血清CEA、CYFRA21-1及ALP联合检测对NSCLC患者发生骨转移具有较好的诊断效能,且上述各项指标水平随转移灶数量增加呈现高表达,但与骨转移病理分型无关,提示上述三项指标可作为肺癌骨转移患者病情变化和预后判断的参考依据。Objective To investigate the diagnostic value of combined detection of serum carcinoembryonic antigen(CEA),cytokeratin 19 fragments antigen 21-1(CYFRA21-1)and alkaline phosphatase(ALP)in bone metastasis of non-small cell lung cancer(NSCLC)patients.Methods A total of 68 patients diagnosed with NSCLC from August 2020 to August 2022 were selected as NSCLC group,according to the results of emission computed tomography(ECT),the patients were divided into bone metastasis group(n=31)and non-bone metastasis group(n=37).In addition,32 patients diagnosed with benign pulmonary lesions during the same period were selected as benign lesion group.The serum indexes of the NSCLC group and the benign lesion group,the bone metastasis group and the non-bone metastasis group were compared,respectively;the receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficacy of serum indexes detection for bone metastasis in NSCLC patients;the serum indexes of patients with different numbers and different pathological types of bone metastases were observed.Results The levels of CEA,CYFRA21-1 and ALP in the NSCLC group were higher than those in the benign lesion group(P<0.05).The levels of CEA,CYFRA21-1 and ALP in the bone metastasis group were higher than those in the non-bone metastasis group(P<0.05).The areas under curve(AUC)of combined detection of CEA,CYFRA21-1 and ALP in the diagnosis of bone metastasis in NSCLC patients was 0.937,which was significantly higher than that of single index detection.The levels of CEA,CYFRA21-1 and ALP in patients with≥3 bone metastases were higher than those in patients with<3 bone metastases(P<0.05).Conclusion The combined detection of serum CEA,CYFRA21-1 and ALP has a good diagnostic efficacy for bone metastasis in patients with NSCLC,and the levels of the above indicators are highly expressed with the increase of the number of metastases,but it is not related to the pathological types of bone metastasis,suggesting that the above three indicators can be used as a reference for

关 键 词：非小细胞肺癌 骨转移 癌胚抗原 细胞角蛋白19片段抗原21-1 碱性磷酸酶 

分 类 号：R734.2[医药卫生—肿瘤]