肿瘤标志物CA19-9、CEA水平与胆囊结石伴胆囊炎患者胆红素水平的相关性分析  

Correlation between Tumor Markers CA19-9 and CEA Levels And Bilirubin Levels in Patients with Gallstones And Cholecystitis

作　　者：莫丽锦 林发全[3] Mo Lijin;Lin Faquan(Key Laboratory of Clinical Laboratory in Guangxi Universities,Nanning Guangxi 530021,China;Medical Laboratory Department of Hechi People's Hospital,Hechi Guangxi 547000,China;Department of Laboratory Medicine,First Affiliated Hospital of Guangxi Medical University,Nanning Guangxi 530021,China)

机构地区：[1]广西高校临床检验重点实验室,广西南宁530021 [2]河池市人民医院医学检验科,广西河池547000 [3]广西医科大学第一附属医院检验科,广西南宁530021

出　　处：《生命科学仪器》2024年第6期5-7,共3页Life Science Instruments

摘　　要：目的分析肿瘤标志物CA19-9、CEA水平与胆囊结石伴胆囊炎患者胆红素水平的相关性。方法回顾性分析2023年1月至2024年5月期间医院收治的104例胆囊结石伴胆囊炎患者,为观察组,将同期在医院体检中心进行健康体检的104例健康者作为对照组。收集两组血清标本,检测血清CA19-9、CEA、TBIL及DBIL水平,分析CA19-9、CEA水平与胆囊结石伴胆囊炎患者胆红素水平的相关性。结果观察组CEA水平与对照组对比,P>0.05;观察组CA19-9、TBIL及DBIL水平均分别高于对照组,P<0.05;经过治疗,观察组CA19-9、CEA、TBIL及DBIL水平均较治疗前显著降低,P<0.05。观察组血清CA19-9、CEA水平与TBIL及DBIL水平呈正相关。结论胆结石伴胆囊炎患者血清CA119-9、TBIL及DBIL水平均呈现上升的趋势,且CA19-9、CEA与胆红素水平呈正相关,可用于胆结石或胆道疾病的诊断及病情评估。Objective:To analyze the correlation between tumor markers CA19-9 and CEA levels and bilirubin levels in patients with gallstones and cholecystitis.Methods:A retrospective analysis was made on 104 patients with gallstones and cholecystitis admitted to the hospital from January 2023 to May 2024.As the observation group,104 healthy people who underwent physical examination in the hospital physical examination center during the same period served as the control group.Serum samples were collected from two groups,and serum levels of CA19-9、CEA、TBIL and DBIL were detected,and the correlation between CA19-9、CEA levels and bilirubin levels in patients with gallstones and cholecystitis was analyzed.Results:Compared with the control group,the CEA level in the observation group was,P>0.05.The levels of CA19-9、TBIL and DBIL in the observation group were higher than those in the control group,respectively,P<0.05;After treatment,the levels of CA19-9、CEA、TBIL and DBIL in the observation group were significantly lower than those before treatment,P<0.05.The levels of serum CA19-9 and CEA in the observation group were positively correlated with the levels of TBIL and DBIL.Conclusion:The serum levels of CA119-9、TBIL and DBIL in patients with cholelithiasis and cholecystitis are on the rise,and CA19-9 and CEA are positively correlated with bilirubin levels,which can be used for the diagnosis and condition evaluation of cholelithiasis or biliary diseases.

关 键 词：肿瘤标志物 糖类抗原 癌胚抗原 胆囊结石 胆囊炎 

分 类 号：R735.8[医药卫生—肿瘤]