丁苯酞注射液联合依达拉奉右莰醇治疗急性进展性脑梗死的近期疗效  

Short-term Efficacy of Butylphthalide Injection Combined with Edaravone Dextromethorphan in the Treatment of Acute Progressive Cerebral Infarction

作　　者：陈莉莉[1] 陈宵仪 徐思敏 肖建伟 Chen Lili;Chen Xiaoyi;Xu Simin;Xiao Jianwei(Zhanjiang Central People's Hospital,Zhanjiang Guangdong 524000)

机构地区：[1]湛江中心人民医院,广东湛江524000

出　　处：《生命科学仪器》2024年第6期130-132,共3页Life Science Instruments

摘　　要：目的探究在急性进展性脑梗死患者治疗中结合应用丁苯酞注射液与依达拉奉右莰醇的近期疗效。方法研究对象均来源于湛江中心人民医院诊治的急性进展性脑梗死患者,诊治时间范围2023年6月至2024年6月,从中纳入100例,随机分入单药干预组(单独应用丁苯酞氯化钠注射液干预)与两药结合组(结合应用结合应用丁苯酞注射液与依达拉奉右莰醇),每组各分入50例。从近期疗效、神经缺损、炎症因子、血清自由基、安全性几方面进行组间总体疗效评估。结果经过治疗,从神经缺损(NIHSS评分)、三项炎症因子(hs-CRP、IL-8、TNF-α)、三项血清自由基(ROS、NO、SOD)来看,两药结合组血清SOD含量比单药干预组更高,其余指标均更低(P<0.05)。从近期疗效与安全性来看,两药结合组总治疗有效率比单药干预组更高(P<0.05);但两者不良反应率无明显差异(P>0.05)。结论在急性进展性脑梗死患者治疗中结合应用丁苯酞注射液与依达拉奉右莰醇对神经缺损、炎症反应、脑损伤均有减轻作用,可保障近期疗效与治疗安全。Objective:To explore the short-term efficacy of butylphthalide injection combined with edaravone in the treatment of patients with acute progressive cerebral infarction.Methods:The subjects were all patients with acute progressive cerebral infarction diagnosed and treated in Zhanjiang Central People's Hospital.The diagnosis and treatment time ranged from June 2023 to June 2024,and 100 cases were included.They were randomly divided into single drug intervention group(intervention with butylphthalide sodium chloride injection alone)and two drug combination group(combined application with butylphthalide injection and edaravone dextromethorphan),with 50 cases in each group.The overall curative effect was evaluated from the aspects of short-term curative effect、nerve defect、inflammatory factors、serum free radicals and safety.Results:After treatment,in terms of nerve defect(NIHSS score)、three inflammatory factors(hs-CRP、IL-8、TNF-α)and three serum free radicals(ROS、NO、SOD),the serum SOD content in the combination of two drugs was higher than that in the single drug intervention group,and the other indexes were lower(P<0.05).In terms of short-term efficacy and safety,the total effective rate of the combination of two drugs was higher than that of the single drug intervention group(P<0.05).However,there was no significant difference in the adverse reaction rate between the two groups(P>0.05).Conclusion:In the treatment of patients with acute progressive cerebral infarction,the combined application of butylphthalide injection and edaravone dextromethorphan can alleviate nerve defect,inflammatory reaction and brain injury,which can ensure the short-term curative effect and treatment safety.

关 键 词：急性进展性脑梗死 依达拉奉右莰醇 丁苯酞注射液 神经缺损 自由基 

分 类 号：R743.3[医药卫生—神经病学与精神病学]