不同防腐剂对皮肤常驻菌的抑制作用研究  

Study on the inhibitory effect of different preservatives on resident bacteria of skin

作　　者：滕贇 刘雅丹[2] TENG Yun;LIU Ya-Dan(Institute for Inner Mongolia and drug testing,Hohhot 010010,China;China Institute for Food and Drug Control,Beijing 102629,China)

机构地区：[1]内蒙古自治区药品检验研究院,呼和浩特010010 [2]中国食品药品检定研究院,北京102629

出　　处：《实验室检测》2024年第10期116-118,共3页Laboratory Testing

摘　　要：目的测定在不同的防腐剂的作用下,皮肤常驻菌的抑制效果。方法结合采集的实时数据先计算出最小抑菌浓度(Minimum inhibitory concentration,MIC)值,设定初始的约束条件后进行菌体的培养,多周期对比菌落数量的变化状态,并测算菌落变动平均值,判定分析此时菌体的处理效果。逐批逐次对测试的溶液进行稀释,针对水溶液、膏状化妆品、粉状化妆品以及液态化妆品四种测试目标的对比,计算出菌体的抑制灭杀对数值。结果在不同的采样样品浓度下,对皮肤的常驻菌进行灭杀与抑制,经过多层级的计算,最终得出的灭杀对数值较高,均可以达到7.5以上。结论防腐剂浓度的增加对皮肤常驻菌的抑制效果基本上处于正向的变化关系,防腐剂的浓度越高,形成的抑制效果越好,反之,防腐剂的浓度越低,形成的抑制效果会相对较差。Objective To determine the inhibitory effect of skin resident bacteria under the action of different preservatives.Methods Combined with the collected real-time data,the minimum inhibitory concentration value(MIC)was calculated first,the initial constraint conditions were set,and then the bacteria were cultured.The change state of the number of colonies was compared in multiple cycles,and the average value of colony change was calculated to determine and analyze the treatment effect of the bacteria at this time.The test solution was diluted batch by batch,and the inhibition and killing pairs of bacteria were calculated according to the comparison of four test targets:aqueous solution,paste cosmetics,powder cosmetics and liquid cosmetics.Results Under different sample concentration,the resident bacteria of skin were killed and inhibited.After multi-level calculation,the final killing pair value was higher,which could reach more than 7.5.Conclusion The inhibitory effect of increasing the concentration of preservatives on resident bacteria in the skin is basically in a positive change relationship.The higher the concentration of preservatives,the better the inhibitory effect will be formed;conversely,the lower the concentration of preservatives,the relatively poor inhibitory effect will be formed.

关 键 词：不同防腐剂 皮肤常驻菌 抑制分析 作用核验 防腐处理 皮肤管理 

分 类 号：TQ658[化学工程—精细化工]