人类子宫内膜的单细胞组学研究进展  

Research Progress in Single-Cell Omics of Human Endometrium

作　　者：姜乐然 张园[2] 王琳[2] 刁飞扬(审校)[2] JIANG Le-ran;ZHANG Yuan;WANG Lin;DIAO Fei-yang(The First Clinical Medical College of Nanjing Medical University,Nanjing 210029,China;Department of Reproductive Medicine,The First Affiliated Hospital with Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一临床医学院,210029 [2]南京医科大学第一附属医院生殖医学中心,210029

出　　处：《国际生殖健康/计划生育杂志》2024年第3期216-221,共6页Journal of International Reproductive Health/Family Planning

基　　金：国家重点研发计划(2022YFC2702505)

摘　　要：子宫内膜中各种亚型细胞的表达和功能对于维持正常子宫内膜功能、提供胚胎植入环境非常重要。近年单细胞组学研究因其可以在单个细胞水平上对不同来源、不同时期子宫内膜进行高通量测序,逐渐成为子宫内膜相关基础研究和临床应用的一个重要研究手段。通过对子宫内膜相关单细胞组学的研究进行综述,包括子宫内膜生理状态,以及复发性流产、子宫内膜异位症、子宫腺肌病、薄型子宫内膜、宫腔粘连、反复种植失败以及子宫内膜癌等病理情况下子宫内膜单细胞层面差异、细胞间相互作用。更深入地理解单细胞组学在子宫内膜研究中的应用,有助于揭示子宫内膜相关疾病的病理生理机制。The expression and function of various subtypes of cells in the endometrium are crucial for maintaining normal endometrial function and providing an environment for embryo implantation.In recent years,the single-cell omics has gradually become an important tool for the basic research and clinical application related to endometrium,as it can perform the high-throughput sequencing of endometrium from different sources and stages at the single-cell level.This article provides a systematic review of existing studies on the single-cell omics related to the endometrium,including the physiological status of the endometrium,as well as the single-cell differences and intercellular interactions in pathological conditions such as recurrent spontaneous abortion,endometriosis,adenomyosis,thin endometrium,intrauterine adhesions,repeated implantation failures and endometrial cancer.The deeper understanding of the application of single-cell omics of endometrium is helpful for us to reveal the pathophysiological mechanisms of the endometrium-related diseases.

关 键 词：子宫内膜 单细胞分析 高通量核苷酸序列分析 容受性 胚胎植入 

分 类 号：R711[医药卫生—妇产科学]