颅内压及miRNA-124与乳酸水平预测重型颅脑损伤预后的研究  

Study on Intracranial Pressure、miRNA-124 And Lactic Acid Levels to Predict the Prognosis of Severe Craniocerebral Injury

作　　者：何英杰 He Yingjie(Department of Neurosurgery,Liwan Central Hospital,Guangzhou Guangdong 510145,China)

机构地区：[1]广州市荔湾中心医院神经外科,广东广州510145

出　　处：《生命科学仪器》2024年第4期79-81,共3页Life Science Instruments

摘　　要：目的研究分析颅内压检测及微小RNA124(microRNA-124,miRNA-124)、乳酸水平对重型颅脑损伤患者预后的预测价值。方法收集2021年9月至2024年4月在广州市荔湾中心医院神经外科进行手术治疗的重型颅脑损伤患者77例,根据术后出院时的预后情况分为存活组与死亡组。所有患者均持续进行颅内压监测,并于术后24 h抽取患者静脉血进行乳酸水平、miRNA-124水平检测。分析颅内压监测、miRNA-124及乳酸水平检测对重型颅脑损伤患者预后的预测作用。结果与死亡组患者相比,存活组患者术后颅内压、miRNA124和乳酸水平均明显更低,P<0.05。颅内压水平对预后的AUC为0.906(95%CI:0.8347~0.9773,P<0.0001);miRNA-124水平对预后的AUC为0.831(95%CI:0.7420~0.9208,P<0.0001);乳酸水平对预后的AUC为0.828(95%CI:0.7388~0.9178,P<0.0001)。结论重型颅脑损伤患者术后颅内压、miRNA-124和乳酸水平与其预后均有一定相关性,这三项指标上升均可预测重型颅脑损伤患者不良预后的发生。Objective:To study and analyze the predictive value of intracranial pressure detection,MicroRNA-124 and lactic acid levels on the prognosis of patients with severe craniocerebral injury.Methods:From September 2021 to April 2024,77 patients with severe craniocerebral injury who underwent surgical treatment in the Department of Neurosurgery,Liwan Central Hospital Guangzhou were divided into survival group and death group according to the prognosis after discharge.Intracranial pressure was continuously monitored in all patients,and the levels of lactic acid and miRNA-124 were detected at 24 h after operation.To analyze the predictive effect of intracranial pressure monitoring、miRNA-124 and lactic acid level detection on the prognosis of patients with severe craniocerebral injury.Results:Compared with the death group,the postoperative intracranial pressure、miRNA124 and lactic acid levels in the survival group were significantly lower,P<0.05.The AUC of intracranial pressure level to prognosis was 0.906(95%CI:0.8347~0.9773,P<0.0001).The AUC of miRNA-124 level for prognosis was 0.831(95%CI:0.7420~0.9208,P<0.0001).The AUC of lactic acid level for prognosis was 0.828(95%CI:0.7388~0.9178,P<0.0001).Conclusion:Postoperative intracranial pressure、miRNA-124 and lactic acid levels in patients with severe craniocerebral injury are all related to their prognosis,and their rising levels can predict the occurrence of adverse prognosis in patients with severe craniocerebral injury.

关 键 词：颅内压 miRNA-124 乳酸 重型颅脑损伤 预后 

分 类 号：R651.1[医药卫生—外科学]