特高海拔地区世居藏族群众胆囊结石影响因素分析  

Influencing factors of cholecystolithiasis among Tibetan residents living at extreme altitude

作　　者：谢毅 周玉坤[1] 拉布夏嘎 于菲菲[3] XIE Yi;ZHOU Yukun;Labuxiaga;YU Feifei(Department of Hepatobiliary,Pancreatic and Splenic Surgery,Naval Medical Center,Naval Medical University(Second MilitaryMedical University),Shanghai 200433,China;Nima County People’s Hospital,Nagqu 853200,Xizang Autonomous Region,China;Department of Quality Management,Medical Security Center,Naval Medical Center,Naval Medical University(SecondMilitary Medical University),Shanghai 200433,China)

机构地区：[1]海军军医大学(第二军医大学)海军特色医学中心肝胆胰脾外科,上海200433 [2]西藏自治区尼玛县人民医院,那曲853200 [3]海军军医大学(第二军医大学)海军特色医学中心医疗保障中心质量管理科,上海200433

出　　处：《海军军医大学学报》2025年第2期263-267,共5页Academic Journal of Naval Medical University

基　　金：海军军医大学(第二军医大学)校级课题(2023QN045);海军军医大学(第二军医大学)海军特色医学中心优秀青年人才项目(21TPQN1601).

摘　　要：目的分析特高海拔地区世居藏族群众胆囊结石的影响因素。方法收集2023年8月10日-17日那曲市尼玛县人民医院组织并协同援藏医师对吉瓦乡藏族群众进行下乡体检的体检数据,并调查记录受检者的一般信息和生活饮食习惯。将入组的448位研究对象根据腹部超声检查结果分为胆囊结石组(106例)和未患胆囊结石组(342例),采用多因素logistic回归分析藏族群众患胆囊结石的影响因素。结果胆囊结石组与未患胆囊结石组的年龄、体重、BMI、收缩压、舒张压、指脉氧和文化程度等变量差异均有统计学意义(均P<0.05)。多因素logistic回归分析显示,年龄(OR=1.062,95%CI 1.020~1.106)、体重(OR=1.120,95%CI 1.067~1.176)、吸烟(OR=4.751,95%CI 1.627~13.869)、胆固醇(OR=1.429,95%CI 1.129~1.810)、酥油茶饮用量(OR=2.123,95%CI 1.656~2.721)、丙氨酸转氨酶(OR=1.045,95%CI 1.028~1.062)、文化程度低(OR=6.994,95%CI 2.615~18.702)、脂肪肝(OR=4.409,95%CI 1.499~12.968)、以荤食为主(OR=3.725,95%CI 1.255~11.055)均与藏族群众患胆囊结石相关。结论特高海拔地区世居藏族群众胆囊结石的发病可能与以上多种因素有关,这为当地胆囊结石的预防、早期诊断和治疗提供了信息和线索。Objective To analyze the influencing factors of cholecystolithiasis among Tibetan residents living at extreme altitude.Methods From Aug.10 to 17,2023,Nima County People’s Hospital in Nagqu,in collaboration with Tibetan-aid doctors,organized physical examinations for Tibetan residents in Jiwa Township.The physical examination data were collected,and the general information and dietary habits of the examinees were recorded.Based on the results of abdominal ultrasound examination,the 448 enrolled participants were assigned to a cholecystolithiasis group(106 cases)and a non-cholecystolithiasis group(342 cases).Additionally,multivariable logistic regression analysis was conducted to investigate the factors influencing the occurrence of cholecystolithiasis among Tibetan residents.Results There were significant differences in age,weight,body mass index,systolic blood pressure,diastolic blood pressure,finger pulse oxygen,and educational level between the 2 groups(all P<0.05).The results of multivariate logistic regression analysis showed that age(odds ratio[OR]=1.062,95%confidence interval[CI]1.020-1.106),weight(OR=1.120,95%CI 1.067-1.176),smoking(OR=4.751,95%CI 1.627-13.869),cholesterol(OR=1.429,95%CI 1.129-1.810),amount of butter tea drink(OR=2.123,95%CI 1.656-2.721),alanine transaminase(OR=1.045,95%CI 1.028-1.062),low educational level(OR=6.994,95%CI 2.615-18.702),fatty liver(OR=4.409,95%CI 1.499-12.968)and meat-based diet(OR=3.725,95%CI 1.255-11.055)were correlated with cholecystolithiasis.Conclusion The incidence of cholecystolithiasis among Tibetan residents living at extreme altitude may be related to various factors mentioned above,which provides clues for the prevention,early diagnosis,and treatment of local cholecystolithiasis.

关 键 词：特高海拔 胆囊结石 危险因素 

分 类 号：R575.62[医药卫生—消化系统]