雷沙吉兰对帕金森病抑郁症状的影响及与抗抑郁药合用的安全性  

Efficacy of rasagiline in depressive symptoms of Parkinson's disease and safety of combination therapy with antidepressants

作　　者：张欣[1] 钱倩 高娟[1,2] 张金库 王楚涵 ZHANG Xin;QIAN Qian;GAO Juan;ZHANG Jinku;WANG Chuhan(Department of Neurology,Baoding No.1 Central Hospital,Baoding,Hebei 071000,China;Hebei Key Laboratory of Molecular Pathology and Early Diagnosis of Tumor,Baoding,Hebei 071000,China;Department of Neurology,Affiliated Hospital of Hebei University,Baoding,Hebei 071000,China)

机构地区：[1]保定市第一中心医院神经内科,河北保定071000 [2]河北省分子病理与肿瘤早期诊断重点实验室,河北保定071000 [3]河北大学附属医院神经内科,河北保定071000

出　　处：《安徽医药》2025年第3期451-455,共5页Anhui Medical and Pharmaceutical Journal

基　　金：保定市科技计划项目(2141ZF249);河北省卫生健康委科研基金项目(20220288)。

摘　　要：帕金森病(PD)是一种常见的中枢神经系统退行性疾病,抑郁是其最常见的非运动症状之一,严重影响病人的生活质量。研究表明雷沙吉兰除可缓解PD运动症状外,还可显著改善其抑郁症状,但因与抗抑郁药合用存在5-羟色胺综合征(SS)的风险,故雷沙吉兰与抗抑郁药合用的安全性一直受到质疑。该研究总结雷沙吉兰对PD抑郁症状的影响及可能的机制;评估雷沙吉兰与抗抑郁药合用的安全性,同时整理了雷沙吉兰参与致病的SS病例;以期指导雷沙吉兰的充分、合理应用,为PD合并抑郁的个体化治疗提供参考。Parkinson's disease(PD)is a common neurodegenerative disease,and depression is one of its most common non-motor symptoms,which severely reduces the quality of life of patients.Some studies have shown that rasagiline can significantly improve the depressive symptoms of PD in addition to the motor symptoms,but its safety has been questioned when combined with antidepressants because of the risk of serotonin syndrome(SS).In this review,we summarized the effects of rasagiline on depressive symptoms in PD and the possible mechanisms,and evaluated the safety of combining rasagiline and antidepressants,while all case reports of SS associated with rasagiline were identified.This review will guide clinicians to use rasagiline more fully and reasonably and provide a reference for the personalized treatment of PD complicated with depression.

关 键 词：帕金森病 抑郁 雷沙吉兰 抗抑郁药 安全性 

分 类 号：R74[医药卫生—神经病学与精神病学]