住院抑郁症病人中西药联合治疗的影响因素分析  

Retrospective analysis of Chinese and western medicine combined treatment and its influencing factors in inpatients with depression

作　　者：郁玉发 易天军[2] 刘佩友 任安俊 徐靖 YU Yufa;YI Tianjun;LIU Peiyou;REN Anjun;XU Jing(School of Pharmacy,Hubei University of Medicine,Shiyan,Hubei 442000,China;Mental Health Center,Shiyan Hospital of Traditional Chinese Medicine,Shiyan,Hubei 442012,China)

机构地区：[1]湖北医药学院药学院,湖北十堰442000 [2]十堰市中医医院精神卫生中心,湖北十堰442012

出　　处：《安徽医药》2025年第3期512-518,共7页Anhui Medical and Pharmaceutical Journal

摘　　要：目的比较抗抑郁西药组与西药联合中草药汤剂组住院病人的临床特征,分析抑郁症病人联合使用中西药抗抑郁的影响因素。方法回顾性分析十堰市中医医院2022年6—12月431例住院病人的临床资料,比较两组病人的用药信息、一般资料、实验室检查报告等,对抑郁症病人的各项资料进行单因素分析和多因素logistic回归分析,探讨联合使用中西药抗抑郁的影响因素。结果431例住院抑郁症病人单纯使用西药214例(西药组),中西药联用217例(联用组),单因素分析显示年龄、病程、复发次数、合并躯体疾病、服药依从性、汉密尔顿抑郁量表(HAMD)评分、匹兹堡睡眠质量指数(PSQI)评分对联合使用中西药差异有统计学意义(P<0.05);多因素回归分析显示年龄、合并躯体疾病、服药依从性、HAMD评分、PSQI评分是中西药联合治疗的独立影响因素。中西药联用组病人住院治疗前焦虑/抑郁程度28(24,30)分较西药组高25(23,27)分(P<0.001)、住院治疗后中西药联用组病人的不良反应显著低于西药组(P<0.05)[消化系统不良反应26(12.1%)比43(20.1%);血液和淋巴系统不良反应17(7.8%)比19(8.9%);心血管系统不良反应11(5.1%)比23(10.7%);神经系统不良反应12(5.5%)比19(8.9%);其他不良反应6(2.8%)比8(3.7%)]。结论中西药联合治疗抑郁症有助于提高抑郁症病人生命质量。中西联合用药应重点关注病人的年龄、合并其他躯体疾病、服药依从性、HAMD评分、睡眠状况等因素。Objective To compare the clinical characteristics of inpatients in antidepressant western medicine group and western medicine combined with Chinese herbal medicine decoction group,and to analyze the influencing factors of antidepressant patients using Chinese and western medicine together.Methods Clinical data of 431 hospitalized patients at Shiyan Traditional Chinese Medicine Hospital from June to December 2022 were retrospectively analyzed,ahd medication information,general information,laboratory test reports between the two groups of patients were compared.The data of patients with depression were analyzed by univariate analysis and multivariate logistic regression analysis,and the influencing factors of combined use of Chinese and western medicine for depression were discussed.Results Among 431 inpatients with depression,214 cases were treated with western medicine alone(western medicine group)and 217 cases were treated with combination of Chinese and western medicine(Combination group).Univariate analysis showed that age,course of disease,relapse times,physical diseases,medication compliance,Hamilton depression scale(HAMD)score and pittsburgh sleep quality index(PSQI)score were statistically significant(P<0.05).Multivariate regression analysis showed that age,physical diseases,medication compliance,HAMD physical illness and PSQI score were the independent influencing factors of combined use of Chinese and western medicine in inpatients with depression.Before hospitalization,the degree of anxiety/depression in patients in the group with combined use of traditional Chinese and Western medicines 28(24,30)points was higher than that in the Western medicine group 25(23,27)points(P<0.001).After hospitalization,the adverse reactions in the group with combined use of traditional Chinese and Western medicines were significantly lower than those in the Western medicine group(P<0.05).Comparisons of adverse reactions were as follows:Adverse reactions in the digestive system[26(12.1%)vs.43(20.1%)];Adverse reactions in th

关 键 词：抑郁症 抗抑郁药 中药 联合用药 回顾性分析 森林图 

分 类 号：R74[医药卫生—神经病学与精神病学]