聚合物胶束在牙周炎治疗中的研究进展  

Research progress of polymer micelles in the treatment of periodontitis

作　　者：杜思雨 陈亚冰 郭怡婧 王雷[1] DU Siyu;CHEN Yabing;GUO Yijing;WANG Lei(Hospital of Stomatology,Jilin University,Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院,吉林省牙发育与颌骨重塑与再生重点实验室,吉林长春130021

出　　处：《口腔生物医学》2025年第1期39-43,共5页Oral Biomedicine

基　　金：吉林省财政厅课题(jcsz2023481-19);吉林省教育厅科技研究计划项目的资助(JJKH20231235KJ);吉林省科技发展项目(YDZJ202301ZYTS013)。

摘　　要：由于牙周特殊的解剖条件,对于深牙周袋、根分叉病变等仅配合牙周基础治疗难以取得理想的治疗效果,局部给药成为常用的辅助治疗方式。聚合物胶束是由含有两亲性嵌段聚合物自组装而形成的纳米颗粒,由于其易于制得、载药性能良好、表面可修饰以及可设计为多种条件响应释放,近年来有大量的研究报道将两亲性聚合物胶束应用于生物医药递送。本文综述胶束的组成、制备、智能响应方式以及其在牙周炎的应用。Due to the unique anatomical conditions of periodontal tissues,achieving an optimal therapeutic effect for deep pockets and root bifurcation lesions with periodontal basic treatment alone is challenging.Therefore,local drug administration has become a common adjuvant therapy.Polymer micelles are nanoparticles formed by self-assembly of amphiphilic block polymers.Because their ease of preparation,excellent drug loading performance,surface modification capabilities,and ability to release drugs under various conditions,numerous studies have reported the application of amphiphilic polymer micelles in biomedical delivery in recent years.This paper provides a comprehensive overview of micelle composition,preparation methods,intelligent response characteristics,and their applications in the field of periodontitis.

关 键 词：牙周炎 聚合物胶束 纳米载药系统 局部给药系统 

分 类 号：R781.4[医药卫生—口腔医学]