骨形成蛋白对骨再生中血管化调节作用的研究进展  

Research progress on the regulatory role of bone morphogenetic protein in angiogenesis during bone regeneration

作　　者：周子豪 林淑贤 张旗[1] ZHOU Zihao;LIN Shuxian;ZHANG Qi(Shanghai Engineering Research Center of Tooth Restoration and Regeneration,Tongji Research Institute of Stomatology,Department of Endodontics,Stomatological Hospital and Dental School,Tongji University,Shanghai 200072,China)

机构地区：[1]同济大学附属口腔医院牙体牙髓科,同济大学口腔医学院,上海牙组织修复与再生工程技术研究中心,同济大学口腔医学研究所,上海200072

出　　处：《口腔生物医学》2025年第1期44-47,共4页Oral Biomedicine

基　　金：国家自然科学基金(82170945,82370950)。

摘　　要：骨再生中血管化与成骨密切相关,当血管形成受损时,骨再生的预后较差。目前临床上,骨形成蛋白(BMP)2是使用广泛、成骨效果较好的生长因子,随着对BMP的研究深入,其对血管化的调控作用亦可能是促进骨再生的重要途径。本文就近年来BMP对参与骨再生血管化的多种细胞成血管功能的调节作用进行综述,以期为骨再生的临床治疗提供参考和理论依据。Angiogenesis and osteogenesis are intimately linked in bone regeneration.Bone morphogenetic protein 2(BMP2) is currently the most commonly used BMP in clinical practice.As our understanding of BMP deepens,their regulatory influence on angiogenesis emerges as a crucial pathway in promoting bone regeneration.Hence,this paper provides an overview of BMP's modulation of angiogenic functions in various cell types involved in bone regeneration,aiming to offer insights and theoretical foundations for clinical interventions in bone regeneration.

关 键 词：骨再生 骨形成蛋白 血管化 内皮细胞 

分 类 号：R780.2[医药卫生—口腔医学]