γδ T细胞介导的肿瘤免疫机制及其在免疫治疗中的应用  

Antitumor mechanism of action of γδ T cells and prospect of immunotherapy

作　　者：马艺宁 刘晓 程雪 乔春燕[1] 安政雯 MA Yining;LIU Xiao;CHENG Xue;QIAO Chunyan;AN Zhengwen(Department of Oral Pathology,The Hospital of Stomatology,Jilin University,Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,Changchun 130021,China;Department of Oral Biology,The Hospital of Stomatology,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院病理科,吉林省牙发育及颌骨重塑与再生重点实验室,吉林长春130021 [2]吉林大学口腔医学院口腔生物学教研室,吉林长春130021

出　　处：《口腔生物医学》2025年第1期48-52,共5页Oral Biomedicine

基　　金：吉林省自然科学基金项目(YDZJ202201ZYTS039)。

摘　　要：与传统的αβ T细胞不同,γδ T细胞通过非依赖性主要组织相容性复合物(MHC)途径识别抗原,因此在癌症免疫治疗中具有独特优势。本文综述了γδ T细胞的主要亚群及其在介导肿瘤免疫中的关键作用机制、探讨了基于γδ T细胞的免疫治疗策略,同时分析了其临床应用面临的挑战和局限。通过结合现有的研究进展,本文为包括口腔鳞癌在内的多种肿瘤的免疫治疗提供新的理论和研究方向。Unlike conventional αβ T cells,γδ T cells recognize antigens through a non-MHC-dependent pathway,granting them unique advantages in cancer immunotherapy.In this review,we summarize the major subpopulations of γδ T cells and their critical mechanisms in mediating tumor immunity.We further explore the immunotherapeutic strategies based on γδ T cells and analyze the challenges and limitations associated with their clinical applications.By integrating current research advances,this review provides new theoretical insights and research directions for immunotherapy of various cancers,including oral squamous cell carcinoma.

关 键 词：ΓΔT细胞 肿瘤免疫 免疫疗法 

分 类 号：R780.2[医药卫生—口腔医学]