Surface-enhanced Raman scattering on nanomaterials for cancer and pathogens diagnosis  

作　　者：Jingjing Wu Baohong Zhang Lei Xu Yanyu Zhao Tao Chen Jie Lin Anran Li 

机构地区：[1]School of Engineering Medicine,Beihang University,Beijing 100191,China [2]Key Laboratory of Big Data-Based Precision Medicine,Ministry of Industry and Information Technology of the People’s Republic of China,Beihang University,Beijing 100191,China [3]School of Optics and Photonics,Beijing Institute of Technology,Beijing 100089,China [4]Shanxi Lu'an Taihang Lubricant Technology Co.,Ltd.,Changzhi 046204,China [5]Cixi Institute of Biomedical Engineering,Ningbo Institute of Materials Technology and Engineering,Chinese Academy of Sciences,Ningbo 315201,China

出　　处：《Nano Research》2025年第2期650-674,共25页纳米研究(英文版)

基　　金：This work was supported by National Natural Science Foundation of China(Nos.62401053 and 12374390);the Fundamental Research Funds for the Central Universities,the member of Youth Innovation Promotion Association Foundation of CAS,China(No.2023310);the Key Scientific and Technological Special Project of Ningbo City(No.2023Z209).

摘　　要：Surface-enhanced Raman scattering(SERS)is a non-invasive spectroscopic technique that provides specific chemical fingerprint information for biomarkers in cancer and pathogen diagnosis.However,the SERS strategies are limited by the non-specific interactions between substrates and co-existing substances in biological matrices and the challenges of obtaining molecular fingerprint information from the complex vibrational spectrum.In recent years,the rapid development of novel substrates with high SERS activity has opened up new opportunities for their applications in cancer and pathogen diagnosis.The aim of this review is to present the recent progress and perspectives of novel SERS-based substrates for cancer and pathogen diagnostic applications.First,we will introduce recently developed SERS-active nanomaterials and discuss the influencing factors of the SERS signals.Second,the advantages of SERS in the diagnosis of cancer and pathogens will be given.Third,we will review the latest breakthroughs in cancer and pathogen detection research with SERS technology,as well as the new opportunities for SERS applications brought about by artificial intelligence(Al)technology.In addition,the novel microfluidic-SERS platforms for cancer and pathogens diagnosis will also be discussed.Finally,we will summarize the challenges and future perspectives of SERS technology in the field of early cancer diagnosis and rapid pathogen detection.It is highly expected that this review could benefit a comprehensive understanding of the research status of the SERS-active nanomaterials and arouse the research enthusiasm for them,leading to accelerated clinical translation of SERS technology in cancer and pathogen diagnosis.

关 键 词：surface-enhanced Raman scattering(SERS) SERS-active nanomaterials cancer and pathogen diagnosis artificial intelligence(Al)technology 

分 类 号：R73[医药卫生—肿瘤]