红花中一个炔类和两个苯丙素衍生物  

An alkyne and two phenylpropanoid derivants from Carthamus tinctorius L.

作　　者：乔霖清 夏格格 李瑛杰 赵文萱 王彦志[1] QIAO Lin-qing;XIA Ge-ge;LI Ying-jie;ZHAO Wen-xuan;WANG Yan-zhi(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046

出　　处：《药学学报》2025年第1期185-190,共6页Acta Pharmaceutica Sinica

摘　　要：采用MCI Gel CHP-20、ODS、硅胶、Sephadex LH-20柱色谱柱以及半制备液相等方法对红花(Carthamus tinctorius L.)乙醇提取物的正丁醇萃取部位的化学成分进行分离纯化,得到1个炔烃和2个苯丙素类衍生物。运用现代波谱学方法(1D NMR、2D NMR、UV、IR和MS)鉴定结构分别为(5R,E)-十四碳-12-烯-8,10-二炔-1,5,14-三醇(1)、(E)-8-O-β-D-吡喃葡萄糖肉桂酸丁酯(2)和(7S,8S)-7-(4-羟基-3,5-二甲氧基苯)-7-正丁基-8,9-二醇(3)。1~3均为新化合物。对化合物1~3进行体外抗肾纤维化活性筛选,均未表现出明显活性。The chemical constituents from the n-butanol fraction of ethanol extract of safflower(Carthamus tinctorius L.)were isolated and purified using chromatographic process including MCI Gel CHP-20,ODS,Sephadex LH-20 column chromatography,and semi-preparative HPLC method,and one alkyne and two phenylpropanoid derivants were obtained.Their structures were identified as(5R,E)-tetradecane-12-ene-8,10-diyne-1,5,14-triol(1),(E)-8-O-β-D-glucopyranosyl n-butyl cinnamate(2),and(7S,8S)-7-(4-hydroxy-3-methoxybenzene)-7-butyl-8,9-diol(3)by modern spectroscopy methods(1D NMR,2D NMR,UV,IR and MS).1-3 are all new compounds.Compounds 1-3 were screened for their anti-renal fibrosis activities in vitro,and none of them showed obvious effect.

关 键 词：红花 菊科 化学成分 炔烃类 苯丙素衍生物 酶水解 

分 类 号：R284[医药卫生—中药学]