领悟社会支持和TMEM161B基因rs768705多态性及其交互作用与新发抑郁症状的关联  

Interaction between perceived social support and TMEM161B gene rs768705 polymorphism and its association with risk of developing depression

作　　者：牛杏蒙 李涵云 王雪仪 牛四方 秦岩 郑艺 慕福芹 黄悦勤[8] 刘燕 NIU Xingmeng;LI Hanyun;WANG Xueyi;NIU Sifang;QIN Yan;ZHENG Yi;MU Fuqin;HUANG Yueqin;LIU Yan(School of Public Health,Shandong Second Medical University,Weifang 261053,Shandong Province,China;School of Public Health,Jining Medical University,Jining 272013,Shandong Province,China;Cheeloo Medical School,Shandong University,Jinan 250012,China;School of Clinical Medicine,Jining Medical University,Jining 272013,Shandong Province,China;School of Public Health,Binzhou Medical University,Yantai 264003,Shandong Province,China;School of Public Health,Shandong First Medical University and Shandong Academy of Medical Sciences,Jinan 250117,China;School of Mental Health,Jining Medical University,Jining 272013,Shandong Province,China;China Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100083,China)

机构地区：[1]山东第二医科大学公共卫生学院,山东潍坊261053 [2]济宁医学院公共卫生学院,山东济宁272013 [3]山东大学齐鲁医学院,济南250012 [4]济宁医学院临床医学院,山东济宁272013 [5]滨州医学院公共卫生学院,山东烟台264003 [6]山东第一医科大学(山东省医学科学院)公共卫生与健康管理学院,济南250117 [7]济宁医学院精神卫生学院,山东济宁272013 [8]北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100083

出　　处：《中国心理卫生杂志》2025年第2期107-114,共8页Chinese Mental Health Journal

基　　金：泰山学者青年专家人才项目(tsqn201909145);济宁市重点研发计划(2023YXNS102,2023YXNS213)。

摘　　要：目的:探讨领悟社会支持和TMEM161B基因rs768705多态性及其交互作用与大学新生新发抑郁症状的关联。方法:于2018-2020年期间采用整群抽样方式对两所医科大学9928名新生进行基线和2年随访调查。采用自编社会人口学特征问卷收集基本人口学特征信息,采用领悟社会支持量表、贝克抑郁量表、贝克焦虑量表和青少年负性生活事件量表等自评量表测量个体领悟社会支持水平、抑郁症状、焦虑症状和负性生活事件数量。同时,采集血液样本并进行DNA分型测序。结果:家庭支持、其他支持与大学新生新发抑郁症状均呈负关联(OR=0.96,95%CI:0.93~0.99;OR=0.94,95%CI:0.91~0.98)。朋友支持与大学新生新发抑郁症状无关联(OR=0.99,95%CI:0.95~1.02)。rs768705多态性(AG基因型)与大学新生新发抑郁症状呈正关联(OR=1.58,95%CI:1.12~2.23)。朋友支持与rs768705多态性(AG基因型)的交互作用(OR=1.13,95%CI:1.02~1.26)及其他支持与rs768705多态性(AG基因型)的交互作用(OR=1.13,95%CI:1.02~1.25)对女性大学新生新发抑郁症状的影响有统计学意义,而对男性大学新生的影响无统计学意义。结论:领悟社会支持和TMEM161B基因rs768705多态性及其交互作用是影响大学新生新发抑郁症状的关联因素,且具有性别差异。Objective:To explore the association between perceived social support,TMEM161B gene rs768705 polymorphism,and their interaction with incidence of depressive symptoms in the freshmen.Methods:A total of 9928 freshmen from two medical universities were investigated at baseline and follow-up two years later during 2018-2020 by cluster sampling.A self-report demographic characteristics questionnaire was used to collect information of general demographic characteristics.Perceived Social Support Scale,Beck Depression Inventory,Beck Anxiety Inventory and Adolescent Self-Rating Life Events Check List were used to measure the level of perceived social support,depressive symptoms,anxiety symptoms and the number of negative life events of individuals.Blood samples were collected and typed for DNA by professionals.Results:Family support and other support were all negatively associated with depressive symptoms in the freshmen(OR=0.96,95%CI:0.93-0.99;OR=0.94,95%CI:0.91-0.98).There was no correlation between friend support and depressive symptoms in the freshmen(OR=0.99,95%CI:0.95-1.02).TMEM161B gene rs768705 polymorphism(AG)was positively associated with depressive symptoms in the freshmen(OR=1.58,95%CI:1.12-2.23).The interactions of friend support with TMEM161B gene rs768705 polymorphism(AG)(OR=1.13,95%CI:1.02-1.26)and other support with TMEM161B gene rs768705 polymorphism(AG)(OR=1.13,95%CI:1.02-1.25)had significant effects on the incidence of depressive symptoms in the females and no significant effect in the males.Conclusion:The perceived social support,TMEM161B gene rs768705 polymorphism and their interaction are associated with influence of depressive symptoms,and have sex difference in the freshmen.

关 键 词：抑郁症状 大学新生 领悟社会支持 基因多态性 交互作用 

分 类 号：R749.4[医药卫生—神经病学与精神病学]