肺黏膜相关淋巴组织淋巴瘤研究进展  

Research Progress of Pulmonary Extranodal Marginal Zone Lymphoma

作　　者：张少伟 Shaowei ZHANG(Department of Cardiothoracic Surgery,Pingdingshan Medical District,989th Hospital of Joint Logistics Support Force,Pingdingshan 467021,China)

机构地区：[1]联勤保障部队第九八九医院心胸外科(平顶山院区),平顶山467021

出　　处：《中国肺癌杂志》2024年第12期947-955,共9页Chinese Journal of Lung Cancer

摘　　要：黏膜相关淋巴组织(mucosa-associated lymphoid tissue, MALT)淋巴瘤是肺原发性淋巴瘤中最常见的病理类型,是一种惰性淋巴瘤,其发病与慢性炎症刺激及自身免疫性疾病关系密切,临床表现无特异性且发病率低,常易误诊,明确诊断后最佳治疗措施也存在一定争议。本文综述了肺MALT淋巴瘤的流行病学、发病机制、临床表现、计算机断层扫描(computed tomography, CT)特征、病理诊断、治疗及预后等情况,为进一步认识该病提供参考。Mucosa-associated lymphoid tissue(MALT)lymphoma is the most common primary pulmonary lym-phoma,which is an indolent B-cell lymphoma thought to originate from marginal zone B cells.Its pathophysiology is closely related to chronic antigenic stimulation,regardless of whether the antigens are auto-antigens or of microbial origin.Due to its nonspecific clinical presentation and low prevalence,pulmonary MALT lymphoma is often misdiagnosed.The disease is slow-growing,and different treatments have shown good efficacy,but its optimal treatment is somewhat controversial.This paper reviews the epidemiology,pathogenesis,clinical manifestations,computed tomography(CT)features,pathological diagnosis,treatment and prognosis of pulmonary MALT lymphoma,providing reference for clinicians to further understanding of the disease.

关 键 词：黏膜相关淋巴组织淋巴瘤 肺原发性淋巴瘤 NF-ΚB信号通路 利妥昔单抗 抗生素 

分 类 号：R73[医药卫生—肿瘤]