胃癌患者血清IGFBP1表达水平与临床病理特征的相关性及其诊断价值  

Correlation between serum IGFBP1 expression level and clinicopathological features and its diagnostic value in patients with gastric cancer

作　　者：王海晶 米思蓉[1] 高晶 Wang Haijing;Mi Sirong;Gao Jing(Department of Clinical Laboratory,Affiliated Hospital of Yan'an University,Yan'an 716000,China;Department of Gastroenterology,Affiliated Hospital of Yan'an University,Yan'an 716000,China)

机构地区：[1]延安大学附属医院检验科,陕西省716000 [2]延安大学附属医院消化内科,陕西省716000

出　　处：《中华消化病与影像杂志(电子版)》2025年第1期11-15,共5页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

基　　金：陕西省教育厅专项科研计划项目(20JK0981)。

摘　　要：目的探究胃癌患者血清胰岛素样生长因子结合蛋白1(IGFBP1)表达水平与临床病理特征的相关性及其诊断价值。方法回顾性选取2021年1月至2023年12月延安大学附属医院诊治的胃癌患者192例为胃癌组,胃良性病变患者192例为对照组,采用酶联免疫吸附法(ELISA)检测研究对象血清IGFBP1表达水平。收集整理患者一般资料和临床病理特征,分析不同资料和临床病理特征患者血清IGFBP1表达水平的差异,绘制受试者工作特征曲线(ROC)评估血清IGFBP1表达水平对胃癌的诊断价值。结果胃癌组幽门螺杆菌感染、胃癌家族史、饮酒、高盐辛辣饮食患者比例显著高于对照组(均P<0.05)。胃癌组血清IGFBP1表达水平显著高于对照组(P<0.001)。低分化程度、Ⅲ~Ⅳ期、浸润深度T4期、有淋巴结转移和有远端转移患者血清IGFBP1表达水平显著高于高/中分化程度、Ⅰ~Ⅱ期、浸润深度T1~T3期、无淋巴结转移、无远端转移患者(均P<0.001)。血清IGFBP1高表达组低分化程度、Ⅲ~Ⅳ期、浸润深度T4期、有淋巴结转移、有远端转移患者比例显著高于低表达组(均P<0.001)。ROC分析结果显示,血清IGFBP1表达水平的AUC为0.800,当取cut-off值40.755时,灵敏度为0.656,特异度为0.964。结论胃癌患者血清IGFBP1表达水平显著升高,且与临床病理特征密切相关,尤其是低分化、晚期、高浸润深度及存在转移的患者,其表达水平更高,具有潜在的胃癌诊断价值。Objective To explore the correlation between the expression level of serum insulin-like growth factor binding protein 1(IGFBP1)and clinicopathological features and its diagnostic value in patients with gastric cancer.Methods A total of 192 patients with gastric cancer diagnosed and treated in Affiliated Hospital of Yan'an University from January 2021 to December 2023 were retrospectively selected as the gastric cancer group and 192 patients with benign gastric lesions as the control group.Serum IGFBP1 expression levels of the subjects were detected by enzyme-linked immunosorbent assay(ELISA).General data and clinicopathological features of patients were collected and sorted out,differences in serum IGFBP1 expression levels of patients with different data and clinicopathological features were analyzed,and receiver operating characteristic curve(ROC)was drawn to evaluate the diagnostic value of serum IGFBP1 expression levels in gastric cancer.Results The proportions of patients with Helicobacter pylori infection,family history of gastric cancer,drinking and high-salt spicy diet in gastric cancer group were significantly higher than those in control group(all P<0.05).The serum IGFBP1 expression level in gastric cancer group was significantly higher than that in control group(P<0.001).The serum IGFBP1 expression level in patients with low differentiation,stageⅢ-Ⅳ,depth of invasion stage T4,lymph node metastasis and remote metastasis was significantly higher than that in patients with high/moderate differentiation,stageⅠ-Ⅱ,depth of invasion stage T1-T3,no lymph node metastasis and no remote metastasis(all P<0.001).The proportion of patients with low differentiation,stageⅢ-Ⅳ,T4 stage of infiltration,lymph node metastasis and remote metastasis in serum IGFBP1 high expression group was significantly higher than that in low expression group(all P<0.001).ROC analysis results showed that the AUC of serum IGFBP1 expression level was 0.800,and when the cut-off value was 40.755,the sensitivity was 0.656 and the spe

关 键 词：胃癌 胃良性病变 胰岛素样生长因子结合蛋白1 临床病理特征 诊断 

分 类 号：R73[医药卫生—肿瘤]