血清SAA、sIL-2R水平与内镜逆行胰胆管造影术后胰腺炎严重程度的相关性及预测价值  

Correlation and predictive value of serum SAA and sIL-2R levels on the severity of pancreatitis after ERCP

作　　者：王春莹 江永强 韩海静 苏红霞 李转 党飞 折彤 屈耀宁 Wang Chunying;Jiang Yongqiang;Han Haijing;Su Hongxia;Li Zhuan;Dang Fei;She Tong;Qu Yaoning(Department of Gastroenterology,Norinco General Hospital,Xi'an 710065,China)

机构地区：[1]兵器工业总医院消化内科,西安710065

出　　处：《中华消化病与影像杂志(电子版)》2025年第1期46-50,共5页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的分析血清淀粉样蛋白A(SAA)、可溶性白细胞介素2受体(sIL-2R)与经内镜逆行胰胆管造影(ERCP)术后胰腺炎严重程度的相关性及预测价值。方法选取2019年1月至2024年1月在兵器工业总医院接受ERCP术的120例患者为研究对象,按患者术后胰腺炎的发生情况分为胰腺炎组(n=43)、对照组(n=77),再将胰腺炎组依据APACHEⅡ系统分为轻症组、重症组两个亚组。比较术后6 h、12 h、24 h各组及各亚组间的血清SAA、sIL-2R变化,采用Pearman分析术后SAA、sIL-2R水平与胰腺炎严重程度的相关性,绘制ROC曲线分析术后各时间段SAA、sIL-2R单独和联合检测对术后胰腺炎的预测价值。结果胰腺炎组患者的术后6 h、12 h、24 h血清SAA、sIL-2R水平比对照组明显升高,差异均有统计学意义(P<0.05);各亚组间的术后6 h、12 h、24 h血清SAA、sIL-2R水平比较,差异均有统计学意义(P<0.05);术后血清SAA联合sIL-2R检测对术后胰腺炎的预测特异性、敏感性高于单独指标预测(P<0.05)。结论血清SAA、sIL-2R水平同ERCP术后胰腺炎的严重程度有一定的关联。术后血清SAA联合sIL-2R检测可用于预测ERCP术后胰腺炎的发生风险,可帮助ERCP术后胰腺炎的早期防控与风险评估。Objective To analyze the correlation and predictive value of serum amyloid A(SAA)and soluble interleukin-2 receptor(sIL-2R)on the severity of pancreatitis after endoscopic retrograde cholangiopancreatography(ERCP).Methods A total of 120 patients who underwent ERCP in Norinco General Hospital from January 2019 to January 2024 were selected as the research object,and they were divided into pancreatitis group(n=43)and control group(n=77)according to the occurrence of postoperative pancreatitis,and then the pancreatitis group was divided into mild group and severe group by APACHEⅡsystem.The changes of serum SAA and sIL-2R in each group and each subgroup were compared at 6 h,12 h and 24 h after operation.Pearman was used to analyze the correlation between severity of postoperative pancreatitis and SAA,sIL-2R at 6 h,12 h and 24 h after operation.The ROC curve was drawn to analyze the predictive value of serum SAA and sIL-2R single and combined detection at different time periods after operation for postoperative pancreatitis.Results The levels of serum SAA and sIL-2R in pancreatitis group were significantly higher than those in control group at 6 h,12 h and 24 h after operation,with statistically significant differences(P<0.05).There were statistically significant differences on serum SAA and sIL-2R levels at 6 h,12 h and 24 h after operation among subgroups(P<0.05).The specificity and sensitivity of serum SAA combined with sIL-2R in the prediction of postoperative pancreatitis were higher than those of single index(P<0.05).Conclusion Serum SAA and sIL-2R levels are related to the severity of pancreatitis after ERCP.The detection of serum SAA combined with sIL-2R after ERCP can be used to predict the risk of pancreatitis after ERCP,and can help the early prevention and control of pancreatitis after ERCP and risk assessment in the clinic.

关 键 词：胰腺炎 内镜逆行胰胆管造影术 淀粉样蛋白A 可溶性白细胞介素2受体 预测价值 

分 类 号：R576[医药卫生—消化系统]