经腹超声黏膜下层指数结合hs-CRP、IL-6、IL-8对溃疡性结肠炎患者早期治疗效果的预测价值  

Predictive value of transabdominal ultrasound submucosal index combined with hs-CRP,IL-6 and IL-8 in the early treatment of ulcerative colitis patients

作　　者：薛伟 祝华[2] 贾涛[1] Xue Wei;Zhu Hua;Jia Tao(Department of Functional Medicine,Emeishan People's Hospital,Emeishan 614200,China;Department of Gastroenterology,Emeishan People's Hospital,Emeishan 614200,China)

机构地区：[1]峨眉山市人民医院功能科,四川省614200 [2]峨眉山市人民医院消化内科,四川省614200

出　　处：《中华消化病与影像杂志(电子版)》2025年第1期55-59,共5页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的探讨经腹超声黏膜下层指数结合高敏C反应蛋白(hs-CRP)、白细胞介素(IL)-6、IL-8对溃疡性结肠炎患者早期治疗效果的预测价值。方法选取2021年1月1日至2022年12月31日在峨眉山市人民医院治疗的溃疡性结肠炎患者作为研究对象,治疗后对治疗效果进行早期判断,根据治疗效果分为缓解组和未缓解组,对比两组患者间的经腹超声结果及临床检验指标,评估经腹超声结合检验指标预测早期治疗效果的价值。结果共92例溃疡性结肠炎患者纳入研究,其中缓解组56例(60.87%)、未缓解组36例(39.13%)。缓解组hs-CRP、IL-8、IL-6与未缓解组对比,差异均有统计学意义(P<0.05);两组体重指数、并发症、红细胞沉降率、白细胞、血红蛋白、溃疡性结肠炎内镜下严重程度指数对比,差异均无统计学意义(P>0.05);两组黏膜下层厚度、黏膜下层指数对比,差异均有统计学意义(P<0.05);两组肠壁厚度对比,差异无统计学意义(P>0.05)。将有统计学意义的因素纳入二元多因素logistic回归,提示hs-CRP、IL-8、IL-6、黏膜下层指数是溃疡性结肠炎早期治疗效果的影响因素(P<0.05)。ROC曲线显示,hs-CRP、IL-6、黏膜下层指数单独预测溃疡性结肠炎患者早期治疗效果较好,曲线下面积分别为0.769、0.772、0.779,IL-8预测效果一般,曲线下面积为0.678;黏膜下层指数结合hs-CRP、IL-8、IL-6对预测溃疡性结肠炎患者早期疗效的准确性较高(P<0.05)。结论经腹超声黏膜下层指数结合hs-CRP、IL-8、IL-6预测溃疡性结肠炎患者早期治疗效果具有较高价值。Objective To explore the predictive value of transabdominal ultrasound submucosal index combined with highly sensitive C-reactive protein(hs-CRP),interleukin(IL)-6,and IL-8 in the early treatment of ulcerative colitis patients.Methods Patients with ulcerative colitis treated at the Emeishan People's Hospital from January 1,2021 to December 31,2022 were selected as the research objects.The treatment effect was evaluated early after treatment,and the patients were divided into a remission group and an unrelieved group based on the treatment effect.The transabdominal ultrasound results and clinical test indicators were compared between the two groups of patients,and the value of the transabdominal ultrasound combined with test indicators for predicting early treatment effect was evaluated.Results A total of 92 patients with ulcerative colitis were included in the study,of which 56 cases(60.87%)were in the remission group and 36 cases(39.13%)were in the unrelieved group.The differences in hs-CRP,IL-8,IL-6 between the remission group and the unrelieved group were statistically significant(P<0.05).However,there were no statistically significant differences in body mass index,complications,erythrocyte sedimentation rate,white blood cell,hemoglobin,and ulcerative colitis endoscopic severity index(P>0.05).The differences in submucosal thickness and submucosal index between the two groups were statistically significant(P<0.05).In terms of intestinal wall thickness,there was no statistically significant difference between the two groups(P>0.05).The above statistically significant factors were included in the binary multivariate logistic regression,and the results showed that hs-CRP,IL-8,IL-6,and submucosal index were the influencing factors for the early treatment effect of ulcerative colitis(P<0.05).The ROC curve results showed that hs-CRP,IL-6,and submucosal index alone had a better predictive effect on early treatment of ulcerative colitis patients,with areas under the curve of 0.769,0.772 and 0.779,respectively.However,

关 键 词：溃疡性结肠炎 超声检查 高敏C反应蛋白 白细胞介素-6 白细胞介素-8 黏膜下层指数 

分 类 号：R57[医药卫生—消化系统]