GPX4 rs2074452与非贲门胃癌变易感性的关联研究  

Association of GPX4 rs2074452 with susceptibility to non-cardia gastric cancer

作　　者：陈雅茹 董文杰[1] 高芳[2] 贾彦彬[1] CHEN Yaru;DONG Wenjie;GAO Fang;JIA Yanbin(School of Basic Medicine and Forensic Medicine,Baotou Medical College,Baotou 014040,China;School of Medical Technology and Anaesthesia)

机构地区：[1]包头医学院基础医学与法医学院,内蒙古包头014040 [2]包头医学院医学技术与麻醉学院

出　　处：《包头医学院学报》2025年第1期38-42,共5页Journal of Baotou Medical College

基　　金：内蒙古自然科学基金项目(编号:2024MS08079,2021MS08054);包头医学院创新团队(编号:bycxtd-06);包头医学院科学研究基金项目(编号:BYJJ-GDJY202313)。

摘　　要：目的:分析谷胱甘肽过氧化酶4(GPX4)基因单核苷酸多态性(SNP)rs2074452与非贲门胃癌变的关联性。方法:采用病例-对照的方法,收集525例非贲门胃癌患者和506例正常体检者,采用血清学方法检测正常对照中幽门螺杆菌(H.pylori)的感染情况。采用PCR-RFLP法检测GPX4 rs2074452的基因型分布,采用非条件性Logistic回归计算其基因型和等位基因频率,并分析其与H.pylori感染及非贲门胃癌发病风险的关联。结果:rs2074452与H.pylori感染风险无关联,与非贲门胃癌发病风险相关。在隐性模型中,与CC+CT基因型相比,TT基因型降低了非贲门胃癌的发病风险(OR=0.214,95%CI:0.061-0.756)。结论:GPX4 rs2074452的TT基因型可能是非贲门胃癌发病的保护因素。Objective:To analyze the relationship between single nucleotide polymorphism(SNP)rs2074452 of glutathione peroxidase 4(GPX4)gene and non-cardia gastric cancer.Methods:Using a case-control approach,525 patients with non-cardia gastric cancer and 506 normal examiners were collected,and Helicobacter pylori(H.pylori)infection was detected in normal controls using serologic methods.PCR-RFLP method was used to detect the genotype distribution of the GPX4 rs2074452.Unconditional Logistic regression was used to calculate its genotype and allele frequency and analyze its association with H.pylori infection and the risk of non-cardia gastric cancer.Results:rs2074452 was not related with the risk of H.pylori infection,but it was associated with the risk of non-cardia gastric cancer.In the recessive model,the TT genotype reduced the risk of non-cardia gastric cancer compared with the CC+CT genotype(OR=0.214,95%CI:0.061-0.756).Conclusion:The TT genotype of GPX4 rs2074452 may be a protective factor for the development of non-cardia gastric cancer.

关 键 词：谷胱甘肽过氧化酶4 单核苷酸多态性 非贲门胃癌 

分 类 号：R735.2[医药卫生—肿瘤]