帕金森病与骨骼系统相关性的研究进展  

Research progress on the relationship between Parkinson’s disease and the skeletal system

作　　者：张任洁 罗越 鲍波 ZHANG Renjie;LUO Yue;BAO Bo(Department of Pathology and Physiology,Guangdong Medical University,Zhanjiang 524000,China)

机构地区：[1]广东医科大学基础医学院病理生理教研室,广东湛江524000

出　　处：《广东医科大学学报》2025年第1期103-108,共6页Journal of Guangdong Medical University

基　　金：广东省省级科技计划项目(2013B060300038)。

摘　　要：帕金森病(Parkinson’s disease,PD)是一种慢性神经退行性疾病,其特征包括运动和非运动症状,严重限制患者的日常活动。近年来的多项分子、生物学和遗传学研究表明,PD的易感基因在大脑以外的外周器官和组织均有表达,在骨细胞中也有表达。因此,这些研究合理地促使人们思考“帕金森病可能是一种全身性疾病”的观点。目前大量证据表明,帕金森病患者更容易发生骨质疏松和骨折,与年龄相匹配的对照组相比,帕金森病患者的骨折风险显著增加。该文阐述了帕金森病与骨骼系统相关性的研究进展,旨在为帕金森病患者骨骼健康的评估、管理、治疗和潜在研究方向提供参考。Parkinson’s disease(PD)is a chronic neurodegenerative disorder marked by both motor and non-motor symptoms,significantly impeding daily activities.Recent molecular,biological,and genetic investigations reveal the expression of PD susceptibility genes in peripheral organs and tissues,including bone cells,suggesting that PD may be classified as a systemic ailment.Evidence increasingly supports that individuals with PD are at heightened risk for osteoporosis and fractures,displaying a substantially greater incidence of fractures compared to age-matched controls.This article elaborates on the research progress of the correlation between Parkinson’s disease and the skeletal system,aiming to provide a reference for the assessment,management,treatment,and potential research directions of bone health in Parkinson’s disease patients.

关 键 词：帕金森病 骨质疏松症 骨代谢 病理生理机制 

分 类 号：R742.5[医药卫生—神经病学与精神病学]