Magnesium-based nanocomposites for orthopedic applications:A review  

作　　者：Meng Cheng Xigang Liang Lihua Cui Dongyan Guan Yang Qu Jianwu Zhao Kai Guan 

机构地区：[1]Department of Orthopedics,The Second Hospital of Jilin University,Changchun,Jilin Province,130014,P.R.China [2]Department of Operating Theatre,Liangshan People's Hospital,Liangshan,Shandong Province 272600,P.R.China [3]Department of Orthopedics,Binzhou People's Hospital,Binzhou,Shandong Province 256610,P.R.China [4]Key Laboratory of Automobile Materials of Ministry of Education&School of Materials Science and Engineering,Jilin University,Changchun,Jilin Province,130025,P.R.China [5]International Center of Future Science,Jilin University,Changchun,Jilin Province,130025,P.R.China

出　　处：《Journal of Magnesium and Alloys》2024年第11期4335-4362,共28页镁合金学报(英文)

基　　金：Scientific Development Program of Jilin Province(20220204103YY)。

摘　　要：Mg-based materials have potential applications in the field of orthopedics owing to their good biodegradability,biocompatibility,and boneinducing properties.However,during the early application process,their major drawback was rapid degradation rate,which limited their clinical application.Nanoparticles can effectively reinforce the mechanical strength and corrosion resistance of Mg matrices,and different nanoparticles can be selected to achieve different biological functions.Therefore,Mg-based nanocomposites have emerged as a versatile class of degradable implant materials with broad clinical potential.This review summarizes the research progress of Mg-based orthopedic implants,mainly including the reinforcement mechanism of nanoparticles on Mg-based materials,the effects and biological functions of different nanoparticle enhancers,surface modification,and the application of new manufacturing technologies.Furthermore,the degradation process of Mg-based materials and the biological functions of magnesium ion(Mg^(2+))during the degradation process are discussed in detail We focused on the biological mechanisms through which Mg^(2+)promotes bone and vascular formation and inhibits osteoclasts by regulating the immune microenvironment or multiple signaling pathways.Finally,the clinical application of Mg-based orthopedic implants are introduced and the future research directions of Mg-based nanocomposites are discussed.

关 键 词：Magnesium-based nanocomposite Strengthening strategy Mg^(2+) Biodegradable material OSTEOGENESIS 

分 类 号：TB33[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]