乳腺癌并发甲状腺乳头状癌患者ER、PR、Ki-67、HER-2的表达及意义分析  

Analysis of expression and significance of ER,PR,Ki-67,HER-2 in patients with breast cancer complicated with thyroid papillary carcinoma

作　　者：王瑞君 郭建平 郭文科 牛海刚 WANG Rui-jun;GUO Jian-ping;GUO Wen-ke(Department of General Surgery,Fenyang Hospital of Shanxi Province,Fenyang 032200,China)

机构地区：[1]山西省汾阳医院普外科,032200 [2]山西医科大学汾阳学院,032200

出　　处：《中国实用医药》2025年第2期29-33,共5页China Practical Medicine

基　　金：吕梁市重点研发项目(项目编号:2020SHFZ63),项目名称:乳腺癌并发甲状腺癌ER、PR、Ki-67、HER-2表达及意义。

摘　　要：目的研究雌激素受体(ER)、孕激素受体(PR)、Ki-67、人表皮生长因子受体-2(HER-2)在乳腺癌并发甲状腺乳头状癌患者中的表达及意义。方法选取行手术治疗的84例单纯乳腺癌患者、101例单纯甲状腺乳头状癌患者以及9例乳腺癌并发甲状腺乳头状癌患者作为研究对象。分析单纯乳腺癌和单纯甲状腺乳头状癌患者ER、PR、HER-2、Ki-67的表达与临床病理特征的相关性;比较单纯乳腺癌患者与乳腺癌并发甲状腺乳头状癌患者的临床资料;分析乳腺癌并发甲状腺乳头状癌的影响因素。结果单纯乳腺癌患者ER的表达与肿瘤大小呈负相关(r=-0.068,P<0.05),与年龄、月经史、肿瘤分期、淋巴结转移均无相关性(P>0.05);Ki-67的表达与淋巴结转移呈正相关(r=0.213,P<0.05),与年龄、月经史、肿瘤大小、肿瘤分期均无相关性(P>0.05);PR、HER-2的表达与年龄、月经史、肿瘤大小、肿瘤分期、淋巴结转移均无相关性(P>0.05)。单纯甲状腺乳头状癌患者ER、PR、HER-2、Ki-67的表达与淋巴结转移呈正相关(r=0.201、0.288、0.233、0.300,P<0.05);ER、PR、Ki-67的表达与肿瘤分期呈正相关(r=0.231、0.237、0.084,P<0.05);HER-2的表达与肿瘤分期无相关性(P>0.05);ER、PR、HER-2、Ki-67的表达与年龄、月经史、肿瘤大小均无相关性(P>0.05)。单纯乳腺癌患者PR、HER-2的阳性率分别为73.81%、84.52%,与乳腺癌并发甲状腺乳头状癌患者的33.33%、55.56%比较差异有统计学意义(P<0.05);单纯乳腺癌患者与乳腺癌并发甲状腺乳头状癌患者的年龄、月经史、乳腺肿瘤大小、淋巴结转移情况、乳腺肿瘤分期、ER和Ki-67表达情况比较均无统计学意义(P>0.05)。Logistic回归分析显示,PR是乳腺癌并发甲状腺乳头状癌的独立危险因素(P<0.05)。结论乳腺癌与甲状腺乳头状癌发病具有潜在联系,PR的表达是乳腺癌并发甲状腺乳头状癌的独立危险因素,此类患者需在后期复查过程中�Objective To study the expression and significance of eEstrogen receptor(ER),progesterone receptor(PR),Ki-67,human epidermal growth factor receptor-2(HER-2)in patients with breast cancer complicated with thyroid papillary carcinoma.Methods 84 patients with simple breast cancer,101 patients with simple thyroid papillary carcinoma,and 9 patients with breast cancer complicated with thyroid papillary carcinoma were selected as study subjects.Analysis of the correlation between the expression of ER,PR,HER-2,Ki-67 and clinicopathological features in patients with simple breast cancer and simple thyroid papillary carcinoma;comparison of the clinical data of patients with simple breast cancer and patients with breast cancer complicated with thyroid papillary carcinoma;analysis of the influencing factors of breast cancer complicating papillary thyroid carcinoma.Results ER expression in simple breast cancer patients was negatively correlated with tumor size(r=-0.068,P<0.05),but was not correlated with age,menstrual history,tumor staging or lymph node metastasis(P>0.05).Ki-67 expression was positively correlated with lymph node metastasis(r=0.213,P<0.05),but was not correlated with age,menstrual history,tumor size,or tumor staging(P>0.05).PR and HER-2 expression was not correlated with age,menstrual history,tumor size,tumor staging,or lymph node metastasis(P>0.05).The ER,

关 键 词：乳腺癌 甲状腺乳头状癌 激素受体 人表皮生长因子受体-2 KI-67 

分 类 号：R736.1[医药卫生—肿瘤] R737.9[医药卫生—临床医学]