阿司匹林与阿替普酶静脉溶栓联合治疗急性脑梗死的效果和对生活质量的影响观察  

Observation on effect of aspirin and intravenous thrombolytic therapy with alteplase on acute cerebral infarction and its influence on quality of life

作　　者：辛艳平[1] 杨静静 XIN Yan-ping;YANG Jing-jing(Laiyang Central Hospital,Yantai 265200,China)

机构地区：[1]烟台市莱阳中心医院,265200 [2]金乡县人民医院,272200

出　　处：《中国实用医药》2025年第2期91-94,共4页China Practical Medicine

摘　　要：目的观察阿司匹林与阿替普酶静脉溶栓联合治疗急性脑梗死的效果和对生活质量的影响,为临床相关研究提供有益参考。方法选择75例急性脑梗死患者作为研究对象,根据治疗方法差异将其分为对照组(35例)与观察组(40例)。对照组应用阿替普酶静脉溶栓治疗,观察组应用阿司匹林与阿替普酶静脉溶栓联合治疗。比较两组临床疗效以及治疗前后血管内皮功能指标(血浆内皮素、一氧化氮)、血液流变学指标(血浆粘度、全血高切粘度、全血低切粘度)、生活质量[脑卒中专用生活质量量表(SS-QOL)评分]。结果观察组治疗总有效率为90.00%,高于对照组的71.43%,差异显著(P<0.05)。治疗后,两组血浆内皮素低于本组治疗前,血浆一氧化氮高于本组治疗前,且观察组血浆内皮素(69.14±5.23)ng/L低于对照组的(73.98±5.60)ng/L,血浆一氧化氮(58.70±4.33)μmol/L高于对照组的(54.21±4.09)μmol/L(P<0.05)。治疗后,两组血浆粘度、全血高切粘度、全血低切粘度均低于本组治疗前,且观察组血浆粘度(1.56±0.11)mPa·s、全血高切粘度(5.14±0.39)mPa·s、全血低切粘度(8.37±0.85)mPa·s低于对照组的(1.72±0.15)、(5.76±0.43)、(9.23±1.08)mPa·s(P<0.05)。治疗后,两组SS-QOL评分高于本组治疗前,且观察组SS-QOL评分(112.48±13.62)分高于对照组的(101.79±10.05)分(P<0.05)。结论阿司匹林与阿替普酶静脉溶栓联合治疗能够提高急性脑梗死的临床效果,改善其血管内皮功能、血液流变学,提升生活质量。Objective To observe the effect of aspirin and intravenous thrombolytic therapy with alteplase on acute cerebral infarction and its influence on quality of life,so as to provide useful reference for clinical research.Methods 75 cases of acute cerebral infarction were selected as the study subjects and divided into a control group(35 cases)and an observation group(40 cases)according to the difference of treatment methods.The control group was treated with intravenous thrombolytic therapy with alteplase,and the observation group was treated with aspirin and intravenous thrombolytic therapy with alteplase.Both groups were compared in terms of clinical efficacy,vascular endothelial function indexes(plasma endothelin,nitric oxide),hemorheology indexes(plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity)and quality of life[stroke-specific quality of life(SS-QOL)score]before and after treatment.Results The total effective rate of the observation group was 90.00%,which was significantly higher than 71.43% of the control group(P<0.05).After treatment,the plasma endothelin in both groups was lower than that before treatment,and the plasma nitric oxide was higher than that before treatment;the plasma endothelin of(69.14±5.23)ng/L in the observation group was was lower than(73.98±5.60)ng/L in the control group,and the plasma nitric oxide of(58.70±4.33)μmol/L was higher than(54.21±4.09)μmol/L in the control group(P<0.05).After treatment,the plasma viscosity,whole blood high shear viscosity and whole blood low shear viscosity in both groups were lower than those before treatment;in the observation group,the plasma viscosity was(1.56±0.11)mPa·s,the whole blood high shear viscosity was(5.14±0.39)mPa·s,and the whole blood low shear viscosity was(8.37±0.85)mPa·s,which were lower than(1.72±0.15),(5.76±0.43),and(9.23±1.08)mPa·s in the control group(P<0.05).After treatment,SS-QOL score in both groups was higher than that before treatment,and the SS-QOL score of(112.48±13.62)points in the

关 键 词：阿司匹林 阿替普酶静脉溶栓 急性脑梗死 血管内皮功能 生活质量 

分 类 号：R74[医药卫生—神经病学与精神病学]