体脂异常与胃癌风险的相关性研究  

Study on the correlation between abnormal body fat and the risk of gastric cancer

作　　者：常少琼[1,2,3] 郑宇奇 刘炜丽 陈瑞芳[1,3] 侯政昆 李培武[3,4] 陈兴华 CHANG Shaoqiong;ZHENG Yuqi;LIU Weili;CHEN Ruifang;HOU Zhengkun;LI Peiwu;CHEN Xinghua(Health Construction Administration Department,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;The First Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Guangzhou Clinical Research Academy of Chinese Medicine,Guangzhou510405,China;Department of Gastroenterology,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Acupuncture and moxibustion Rehabilitation Department,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广州中医药大学第一附属医院治未病科,广东广州510405 [2]广州中医药大学第一临床医学院,广东广州510405 [3]广东省中医临床研究院,广东广州510405 [4]广州中医药大学第一附属医院脾胃病科,广东广州510405 [5]广州中医药大学第一附属医院针灸康复科,广东广州510405

出　　处：《西部医学》2025年第2期267-272,277,共7页Medical Journal of West China

基　　金：广东省自然科学基金项目(2019A515011145)。

摘　　要：目的探讨体脂异常与胃癌的相关性,指导健康管理。方法收集2018年1月-2019年12月在广州中医药大学第一附属医院体检科进行健康体检人员1341例的体检结果,行回顾性分析。按年龄、性别和幽门螺杆菌(Hp)感染等分组,通过t检验和线性相关分析,分析胃蛋白酶原(PG)、体脂率、体脂相关指标和体脂影响因素之间的相关性。结果纳入者平均体脂率均高于正常标准,男性胃蛋白酶原I(PGI)和PGI/II比率(PG-Ratio)高于女性组(P<0.05)。41~70岁组,无论男女其总胆固醇(TC)、低密度脂蛋白(LDL-C)、血糖(GLU)、PGI和PGII高于16~40岁组(P<0.05)。绝经后女性体脂率、PGI和PGII、BMI、TC、TG、LDL-C、GLU较绝经前增高而PG-Ratio降低(P<0.05)。Hp阳性者的TC、LDL-C、PGI、PGII较Hp阴性者高,Hp阳性组PG-Ratio低于Hp阴性组(均P<0.05)。无论性别或是否Hp感染,PG I和PG II与年龄呈显著正相关(P<0.05)。男性和绝经后女性PG I与体脂率呈显著负相关(P<0.01),但女性绝经前无相关性(P>0.05);Hp阳性者PG-Ratio与体脂率呈显著负相关(P<0.01)。1年后回访,209例出现胃肠不适,胃镜发现男性癌前病变发生率(13.73%)高于女性(6.54%)(P<0.05)。结论体脂异常可能容易感染Hp,触发炎-癌通路,增加胃癌风险。男性较于女性,在此关系中表现更明显。感染Hp、体脂率高的老年男性,可能是胃癌的高危人群。Objective To explore the correlation between abnormal body fat and gastric cancer and guide health management.Methods The physical examination results of 1341 patients who underwent physical examination in physi-cal examination department of The First Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2018 to December 2019 were collected and retrospectively analyzed.The correlations among pepsinogen(PG),body fat percentage,body fat related indexes and influencing factors of body fat were analyzed by t test and linear correlation anal-ysis according to age,sex and Helicobacter pylori infection.Results Average body fat percentage was higher than nor-mal standard,and the ratios of pepsinogen I(PGI)and PGI/II(PG-Ratio)in male group were higher than those in fe-male group(P<0.05).The total cholesterol(TC),low-density lipoprotein(LDL-C),blood glucose(GLU),PGI and PGII in men and women aged 41 to 70 years were higher than those in men and women aged 16 to 40 years(P<0.05).Body fat percentage,PGI and PGII,BMI,TC,TG,LDL-C and GLU were increased,while PG-Ratio was decreased in postmenopausal women compared with premenopausal women(P<0.05).The TC,LDL-C,PGI and PGII in Hp-posi-tive patients were higher than those in Hp-negative patients,and the PG-Ratio in Hp-positive group was lower than that in Hp-negative group(all P<0.05).PG I and PG II were positively correlated with age regardless of sex or Hp infection(P<0.05).There was a significant negative correlation between PG and body fat percentage in male and postmenopausal women(P<0.01),but no correlation between PG and body fat percentage in premenopausal women(P>0.05).There was a significant negative correlation between PG-Ratio and body fat percentage in Hp-positive patients(P<0.01).One year later,209 cases had gastrointestinal discomfort.The incidence of precancerous lesions was higher in males(13.73%)than in females(6.54%)(P<0.05).Conclusion Abnormal body fat may easily infect Hp,touch the in-flammatory-cancer pathway,and increase the risk of ga

关 键 词：胃癌 体脂异常 肥胖 胃蛋白酶原 幽门螺杆菌 相关性研究 

分 类 号：R735.2[医药卫生—肿瘤]