血清sTim-3,SFRP4水平对胃癌根治术后患者复发转移的预测价值  

Predictive Value of Serum sTim-3,SFRP4 Levels for Recurrence and Metastasis in Patients After Radical Gastric Cancer Surgery

作　　者：胡帅 师红利 郝建华 解亦斌 Hu Shuai;Shi Hongli;Hao Jianhua(Department of General Surgery,Department of Gastroenterology,Department of Oncology,Linfen People's Hospital,Linfen,Shanxi 041000,China)

机构地区：[1]临汾市人民医院普通外科,消化科,肿瘤科,山西临汾041000 [2]中国医学科学院北京协和肿瘤医院胰胃外科,北京100021

出　　处：《四川医学》2025年第1期59-63,共5页Sichuan Medical Journal

基　　金：吴阶平医学基金会临床科研专项资助(编号:320.6750.2022-03-19)。

摘　　要：目的探讨血清T细胞免疫球蛋白黏蛋白3(sTim-3),分泌型卷曲相关蛋白4(SFRP4)水平对胃癌根治术后患者复发转移的预测价值。方法选取2018年9月至2020年8月在我院168例行胃癌根治术患者为观察对象,根据术后复发转移情况分为复发转移组(n=83)和未复发转移组(n=85),另取同期130例健康体检者作为对照组。检测术前血清中sTim-3、SFRP4水平;多因素Cox回归分析影响术后3年复发转移的因素;使用受试者工作特性(ROC)曲线分析两血清标志物水平对预后的预测价值。结果与对照组比较,胃癌组血清sTim-3、SFRP4水平显著升高(P<0.05)。复发转移组患者sTim-3、SFRP4水平高于未复发转移组,差异有统计学意义(P<0.05)。TNM分期、浸润深度、淋巴结转移、sTim-3、SFRP4是影响术后复发转移的危险因素(P<0.05)。血清sTim-3、SFRP4水平及二者联合预测胃癌根治术后患者复发转移的ROC曲线下面积分别为0.809、0.780、0.872。结论胃癌根治术后复发患者血清sTim-3、SFRP4水平升高,可作为胃癌根治术后复发转移评估的潜在指标。Objective To investigate the predictive value of T cell immunoglobulin mucin 3(sTim-3)and secreted frizzled related protein 4(SFRP4)for recurrence and metastasis in patients after radical gastric cancer surgery.Methods A total of 168 patients with gastric cancer undergoing radical surgery who were treated in our hospital from September 2018 to August 2020 were regarded as observation subjects.According to postoperative recurrence and metastasis,they were separated into a recurrence and metastasis group(n=83)and a non recurrence and metastasis group(n=85),and another 130 healthy subjects were used as the control group.Preoperative serum levels of sTim-3 and SFRP4 were examined.Multivariate Cox regression was applied to analyze the factors affecting 3-year recurrence and metastasis of gastric cancer after radical surgery.Receiver operating characteristic(ROC)curves were applied to analyze the diagnostic value of serum sTim-3 and SFRP4 levels in predicting the prognosis of patients after radical gastrectomy for gastric cancer.Results Comparing with the control group,the serum levels of sTim-3 and SFRP4 in the gastric cancer group were obviously increased(P<0.05).sTim-3 and SFRP4 levels of patients in the recurrence and metastasis group were higher than those in the non recurrence and metastasis group,and the difference was statistically significant(P<0.05).TNM staging,depth of infiltration,lymph node metastasis,sTim-3,and SFRP4 were all risk factors for recurrence and metastasis in gastric cancer patients after radical surgery(P<0.05).The areas under the ROC curves of serum sTim-3,SFRP4 levels,and their combined prediction for recurrence and metastasis in patients with gastric cancer after radical surgery were 0.809,0.780,and 0.872,respectively.Conclusion The serum levels of sTim-3 and SFRP4 in patients with recurrent gastric cancer after radical gastrectomy are elevated,and they can serve as potential indicators for evaluating recurrence and metastasis after radical gastrectomy.

关 键 词：胃癌 根治术 T细胞免疫球蛋白黏蛋白3 分泌型卷曲相关蛋白4 复发转移 

分 类 号：R735.2[医药卫生—肿瘤]