肠道免疫微环境在炎症性肠病中作用的研究进展  

Advances in Role of Intestinal Immune Microenvironment in Inflammatory Bowel Disease

作　　者：甄丁伟 刘童[2] 高善语[3] ZHEN Dingwei;LIU Tong;GAO Shanyu(The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan,250355;Department of Laboratory,Qilu Hospital of Shandong University,Jinan;Department of Anorectal Surgery,Affiliated Hospital,Shandong University of Traditional Chinese Medicine,Jinan)

机构地区：[1]山东中医药大学第一临床医学院,250355 [2]山东大学齐鲁医院检验科 [3]山东中医药大学附属医院肛肠科

出　　处：《胃肠病学》2024年第6期370-375,共6页Chinese Journal of Gastroenterology

基　　金：山东省自然科学基金面上项目(ZR2021MH399);山东省医药卫生科技项目(202304011527)。

摘　　要：炎症性肠病(IBD)是一类侵袭胃肠道的慢性自身免疫性炎症性疾病,主要分为溃疡性结肠炎和克罗恩病两种类型。研究表明,IBD的发病机制复杂,涉及遗传、微生物、免疫应答以及环境等因素,其中包括免疫细胞、细胞因子和细胞间相互作用的免疫系统异常激活以及免疫微环境改变在IBD的发病过程中起有关键作用。本文就免疫微环境变化对IBD的调控作用及其机制作一综述,旨在为IBD免疫治疗方案的制定提供新的思路和研究方向。Inflammatory bowel disease(IBD)is a group of chronic autoimmune inflammatory disorder that attack the gastrointestinal tract,mainly categorized into two types:ulcerative colitis and Crohn′s disease.Studies have shown that the pathogenesis of IBD is complex,involving genetic,microbial,immune response,and environmental factors.Among them,the abnormal activation of the immune system,including immune cells,cytokines,and cell-to-cell interactions,as well as the alterations of the immune microenvironment,play a key role in the pathogenesis of IBD.This article reviewed the regulatory role and mechanism of immune microenvironmental changes in IBD,with the aim of providing new ideas and research direction for the formulation of immunotherapy regimens for IBD.

关 键 词：免疫微环境 结肠炎 溃疡性 CROHN病 免疫细胞 细胞因子类 

分 类 号：R57[医药卫生—消化系统]