生物组织中氧的监测技术及其应用  

Oxygen Detection Technology and Its Applications in Treatment

作　　者：欧小寒 吴圳城 林慧韫 Xiaohan Ou;Zhencheng Wu;Huiyun Lin(MOE Key Laboratory of OptoElectronic Science and Technology for Medicine,Fujian Provincial Key Laboratory for Photonics Technology,Fujian Normal University,Fujian 350007,P.R.China)

机构地区：[1]医学光电科学与技术教育部重点实验室,福建师范大学光电与信息工程学院,福州350007

出　　处：《福光技术》2024年第2期36-45,共10页FUJIAN OPTICAL TECHNOLOGY

摘　　要：组织氧监测技术在生物医学光子学领域中扮演着至关重要的角色,尤其是在光动力治疗(PDT)中,组织氧的浓度直接影响PDT治疗中活性氧(ROS)的产量。实时监测组织氧浓度对于优化PDT治疗计划和提高治疗效果至关重要。本文阐述了氧的生理作用及其对PDT疗效的影响,介绍了组织氧的直接和间接监测技术,以及氧的调节策略,包括直接氧气递送策略、酶催化产氧递送策略、响应型材料原位产氧递送策略和微生物体供氧递送策略。讨论了这些技术的优势和局限性,旨在为医疗专业人员和科研工作者提供关于组织氧监测技术现状和未来发展的全面指导。Oxygen monitoring technology plays a crucial role in the field of biomedical photonics,especially in photodynamic therapy(PDT),where the concentration of tissue oxygen(O_(2))directly affects the production of reactive oxygen species(ROS)in PDT treatment.Real-time monitoring of^(3)O_(2)concentration is crucial for optimizing PDT treatment plans and improving treatment outcomes.This article discusses the physiological role of^(3)O_(2)and its impact on PDT efficacy,introduces direct and indirect monitoring techniques for 302,and 302 regulation strategies,including direct ^(3)O_(2) delivery strategies,enzyme-catalyzed 302 delivery strategies,in situ 302 production delivery strategies using responsive materials,and microbial^(3)O_(2)delivery strategies.The advantages and limitations of these techniques are discussed,aiming to provide comprehensive guidance to medical professionals and researchers on the current status and future development of^(3)O_(2)monitoring technology.

关 键 词：组织氧 光动力治疗 活性氧 检测技术 调节策略 

分 类 号：R73[医药卫生—肿瘤]