黄芩芍药汤联合美沙拉秦缓释片治疗脾虚湿蕴型溃疡性结肠炎临床研究  

Clinical Study on Huangqin Shaoyao Decoction Combined with Mesalazine Sustained-Release Tablets for Ulcerative Colitis of Spleen Deficiency and Dampness Accumula⁃tion Type

作　　者：杨倩 胡蝶 YANG Qian;HU Die(Digestive Department,Changxing County People′s Hospital,Changxing Zhejiang 313100,China)

机构地区：[1]长兴县人民医院消化内科,浙江长兴313100

出　　处：《新中医》2025年第3期39-43,共5页New Chinese Medicine

摘　　要：目的:观察黄芩芍药汤联合美沙拉秦缓释片治疗脾虚湿蕴型溃疡性结肠炎的疗效。方法:选择2022年3月—2023年10月长兴县人民医院收治的98例溃疡性结肠炎患者,按随机数字表法分为联合组及对照组各49例。对照组接受美沙拉秦缓释片治疗,联合组在对照组基础上接受黄芩芍药汤治疗。2组均连续治疗12周。比较2组临床疗效及不良反应发生率,比较2组治疗前后中医证候积分、改良Mayo评分、Geboes指数及炎性因子[白细胞计数(WBC)、血清C-反应蛋白(CRP)、肿瘤坏死因子-α (TNF-α)]水平的变化。结果:联合组临床疗效总有效率为91.84%(45/49),对照组临床疗效总有效率为77.55%(38/49),2组比较,差异有统计学意义(P<0.05)。治疗后,2组腹泻便溏、黏液脓血便、脘腹胀满、腹部隐痛中医证候积分均较治疗前下降(P<0.05),联合组上述4项中医证候积分均低于对照组(P<0.05)。治疗后,2组改良Mayo评分、Geboes指数均较治疗前下降(P<0.05),联合组改良Mayo评分、Geboes指数均低于对照组(P<0.05)。治疗后,2组WBC、CRP、TNF-α水平均较治疗前下降(P<0.05),联合组上述3项水平均低于对照组(P<0.05)。联合组不良反应发生率为6.12%(3/49),对照组不良反应发生率为8.16%(4/49),2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:黄芩芍药汤联合美沙拉秦缓释片治疗脾虚湿蕴型溃疡性结肠炎疗效较好,可缓解临床症状,减轻疾病活动度,调节炎性因子。Objective:To observe the curative effect of Huangqin Shaoyao Decoction combined with Mesalazine Sustained-Release Tablets on ulcerative colitis of spleen deficiency and dampness accumulation type.Methods:A total of 98 cases of patients with ulcerative colitis admitted to Changxing County People′s Hospital from March 2022 to October 2023 were randomly divided into the combination group and the control group,with 49 patients in each group,using a random number table method.The control group was treated with Mesalazine Sustained-Release Tablets,and the combination group was treated with Huangqin Shaoyao Decoction on the basis of the control group.Both groups received continuous treatment for 12 weeks.Compared the clinical efficacy and incidence of adverse reactions between the two groups,and compared the changes in traditional Chinese medicine syndrome scores,modified Mayo scores,Geboes indexes,and levels of inflammatory factors such as white blood cell count(WBC),serum C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)before and after treatment.Results:The total effective rate of clinical efficacy was 91.84%(45/49)in the combination group,and 77.55%(38/49)in the control group,the difference being significant(P<0.05).After treatment,the traditional Chinese medicine syndrome scores of diarrhea and loose stools,mucous purulent bloody stools,abdominal distension and fullness,and abdominal dull pain in both groups were decreased when compared with those before treatment(P<0.05),and the traditional Chinese medicine syndrome scores in the combination group were lower than those in the control group(P<0.05).After treatment,the modified Mayo scores and Geboes indexes in both groups were declined when compared with those before treatment(P<0.05),and the modified Mayo score and Geboes index in the combination group were lower than those in the control group(P<0.05).After treatment,the levels of WBC,CRP,and TNF-αin both groups were decreased when compared with those before treatment(P<0.05),and the above three lev

关 键 词：溃疡性结肠炎 脾虚湿蕴型 黄芩芍药汤 美沙拉秦缓释片 炎症反应 

分 类 号：R574.62[医药卫生—消化系统]