双相障碍认知损害机制的研究进展  

Research Progress of Mechanisms of Cognitive Impairment in Bipolar Disorder

作　　者：彭燕 崔伟[2] 李孝荻 黄志靖 王琳彦 PENG Yan;CUI Wei;LI Xiaodi;HUANG Zhijing;WANG Linyan(Graduate School of North China University of Science and Technology,Tangshan 063210,China;Department One of Emotional Disorders,the Sixth People's Hospital of Hebei Province/Hebei Mental Health Center,Baoding 071000,China;Department of Sleep,Ganzhou Third People's Hospital,Ganzhou 341000,China)

机构地区：[1]华北理工大学研究生院,河北唐山063210 [2]河北省第六人民医院河北省精神卫生中心情感障碍一科,河北保定071000 [3]赣州市第三人民医院睡眠科,江西赣州341000

出　　处：《医学综述》2025年第5期518-522,528,共6页Medical Recapitulate

基　　金：河北省“三三三人才工程”资助项目(C20231144)。

摘　　要：双相障碍是一种以抑郁发作与躁狂发作交替出现的慢性精神疾病,其有显著的认知受损,且这种认知损害可从急性发作期持续至缓解期,甚至终生存在,严重影响患者职业功能及生存质量。双相障碍的认知损害机制复杂,是多因素相互作用的结果,涵盖大脑结构异常、代谢性疾病、遗传学和神经回路、脑-肠轴系统、免疫紊乱和炎症等方面。目前对其具体作用机制及相互关系的认识尚不完全明确,亟待进一步深入研究,以探寻更为有效的治疗靶点和干预措施,从而改善双相障碍患者的认知功能及预后。Bipolar disorder is a chronic mental illness characterized by alternating episodes of depression and mania.It is associated with significant cognitive impairment that can persist from the acute phase to the remission phase,and even throughout the patient's life,severely affecting their occupational function and quality of life.The mechanisms underlying cognitive impairment in bipolar disorder are complex and result from the interaction of multiple factors,including brain structural abnormalities,metabolic diseases,genetics and neural circuits,the brain-gut axis system,immune disorders,and inflammation.Currently,there is still a lack of a clear understanding of the specific mechanisms and their interrelationships,which necessitates further in-depth research,so as to discover more effective therapeutic targets and intervention measures to improve the cognitive function and prognosis of the patients with bipolar disorder.

关 键 词：双相障碍 认知功能 作用机制 

分 类 号：R749[医药卫生—神经病学与精神病学]