Amorphous curcumin-based hydrogels to reduce the incidence of post-surgical intrauterine adhesions  

作　　者：Wenya Zhang Yuxin He Yun Chu Yuanxin Zhai Song Qian Xinhui Wang Pengju Jiang Pengfei Cui Yin Zhang Jianhao Wang 

机构地区：[1]School of Pharmacy,Changzhou University,Changzhou 213164,P.R.China [2]Jiangsu Trautec Medical Technology Co.,Ltd,Changzhou 213200,P.R.China [3]Department of Gynecology,Changzhou Traditional Chinese Medicine Hospital,Changzhou 213004,P.R.China

出　　处：《Regenerative Biomaterials》2024年第6期85-97,共13页再生生物材料(英文版)

基　　金：supported by the National Key Research and Development Program of China(2023YFE0203500);the National Natural Science Foundation of China(82003670);Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX23_1449);the National Natural Science Foundation of China(22375026);Jiangsu Province College Student Innovation and Entrepreneurship Training Program Project(202310292053Z).

摘　　要：The incidence of intrauterine adhesions(IUA)has increased with the rising utilization of intrauterine surgery.The postoperative physical barrier methods commonly used,such as balloons and other fillers,have limited effectiveness and may even cause further damage to the remaining endometrial tissue.Herein,we developed an injectable thermosensitive hydrogel using Pluronic F127/F68 as pharmaceutical excipients and curcumin as a natural active molecule.The hydrogel effectively addresses solubility and low bioavailability issues associated with curcumin.In vitro,drug release assays revealed that the amorphous curcumin hydrogel promotes dissolution and sustained release of curcumin.In vitro experiments reveal high biocompatibility of the hydrogel and its ability to enhance vascular formation while inhibiting the expression of fibrotic factor TGF-β1.To assess the effectiveness of preventing IUAs,in vivo experiments were conducted using IUA rats and compared with a class III medical device,a new-crosslinked hyaluronic acid(NCHA)gel.According to the study,curcumin hydrogel is more effective than the NCHA group in improving the regeneration of the endometrium,increasing the blood supply to the endometrium and reducing the abnormal deposition of fibrin,thus preventing IUA more effectively.This study provides a promising strategy for treating and preventing IUA.

关 键 词：intrauterine adhesion CURCUMIN injectable hydrogel regeneration of damaged endometrium ANTI-FIBROSIS 

分 类 号：R71[医药卫生—妇产科学]