ANTI-FIBROSIS

作品数：16被引量：107H指数：5
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相关领域：医药卫生更多>>
相关作者：彭娟马晓雯苑媛陈建辉张英启更多>>
相关机构：第四军医大学第四军医大学西京医院中国人民解放军中南大学更多>>
相关期刊：《Asian Journal of Pharmaceutical Sciences》《Burns & Trauma》《World Journal of Surgical Procedures》《Chinese Journal of Integrative Medicine》更多>>
相关基金：国家自然科学基金河北省自然科学基金国家教育部博士点基金高等学校学科创新引智计划更多>>
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Amorphous curcumin-based hydrogels to reduce the incidence of post-surgical intrauterine adhesions被引量：1
《Regenerative Biomaterials》2024年第6期85-97,共13页Wenya Zhang Yuxin He Yun Chu Yuanxin Zhai Song Qian Xinhui Wang Pengju Jiang Pengfei Cui Yin Zhang Jianhao Wang 
supported by the National Key Research and Development Program of China(2023YFE0203500);the National Natural Science Foundation of China(82003670);Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX23_1449);the National Natural Science Foundation of China(22375026);Jiangsu Province College Student Innovation and Entrepreneurship Training Program Project(202310292053Z).
The incidence of intrauterine adhesions(IUA)has increased with the rising utilization of intrauterine surgery.The postoperative physical barrier methods commonly used,such as balloons and other fillers,have limited ef...
关键词：intrauterine adhesion CURCUMIN injectable hydrogel regeneration of damaged endometrium ANTI-FIBROSIS 
Exosome-mediated aptamer S58 reduces fibrosis in a rat glaucoma filtration surgery model被引量：3
《International Journal of Ophthalmology(English edition)》2022年第5期690-700,共11页Qian-Yi Lin Xiang-Ji Li Yu Leng Xiao-Min Zhu Min Tang Yi Lin Wang-Du Luo Bing-Cai Jiang Xia Chen Lin Xie 
National Natural Science Foundation of China (No.81700836,No.81470629,No.81670860);Chongqing Natural Research Foundation (No.cstc 2018jcyj AX0034)。
AIM:To confirm whether exosome-mediated delivery of aptamer S58(Exo-S58) has a better antifibrotic effect than naked S58 in human conjunctival fibroblasts(HCon Fs) and a rat glaucoma filtration surgery(GFS) model.METH...
关键词：NANOMEDICINE EXOSOMES APTAMER drug delivery glaucoma surgery transforming growth factor-beta ANTI-FIBROSIS 
Adipose-derived stem cells inhibit dermal fibroblast growth and induce apoptosis in keloids through the arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 cascade by paracrine被引量：6
《Burns & Trauma》2021年第1期288-298,共11页Jinxiu Yang Shiyi Li Leren He Minliang Chen 
supported by grant from the National Natural Science Foundation of China(No.81772085).
Background:The clinical features of keloids consist of aberrant proliferation,secretion,differentiation and apoptosis of keloid dermis-derived fibroblasts(KFBs).Notably,the apoptosis rate of KFBs is lower than the pro...
关键词：KELOIDS Adipose-derived stem cells FIBROBLASTS Apoptosis ANTI-FIBROSIS CYCLOOXYGENASE-2 Arachidonic acid 
Progress in drug delivery system for fibrosis therapy被引量：2
《Asian Journal of Pharmaceutical Sciences》2021年第1期47-61,共15页Lei Xing Xin Chang Lijun Shen Chenglu Zhang Yatong Fan Chongsu Cho Zhiqi Zhang Hulin Jiang 
financially supported by the National Science and Technology Major Project(2017YFA0205400);the National Natural Science Foundation of China(81773667,81573369);NSFC Projects of International Cooperation and Exchanges(81811540416);the“111”Project from the Ministry of Education of China;the State Administration of Foreign Experts Affairs of China(D17010).
Fibrosis is a necessary process in the progression of chronic disease to cirrhosis or even cancer,which is a serious disease threatening human health.Recent studies have shown that the early treatment of fibrosis is t...
关键词：Fibrotic disease Liver fibrosis Lung fibrosis Kidney fibrosis ANTI-FIBROSIS Drug delivery system 
Chinese herbal protocol anti-fibrosis 1 improves radiation induced fibrosis and its related dysfunctions
《TMR Integrative Medicine》2019年第5期1-9,共9页Dong-Mei Jiang Ying-Ying Jin Liu-Hua Long Li-Jue Zhang Si-Hai Tan Pei-Pei Song Long Zhang Tai Zhang Wen-Hua Zhang Feng-Wei Wang 
Objective: Radiotherapy is the main modality for treatment of malignancies, but radiation fibrosis is a severe side effect of radiotherapy which may cause severe dysfunction of patients. We design a new tr aditional C...
关键词：Radia tion fibr osis TCM SIDE effects Cancer 
Synthesis, anti-fibrosis activity, and quantitative structure-activity relationship studies of 1,3-disubstituted-pyridin-4(1H)-one derivatives
《Journal of Chinese Pharmaceutical Sciences》2016年第6期395-407,共13页彭娟 李乾斌 向红琳 王泽瑜 胡高云 
National Nature Science Foundation of China(Grant No.21172268)
A series of 1,3-disubstituted-pyridin-4（1H）-one derivatives were synthesized. The results of a viability assay on NIH_T3 cells indicated that compound 3m potently inhibited the cell viability with an IC50 value of 2...
关键词：Pyridin-4（1H）-one QSAR Anti-fibrosis agents 
An Ac-SDKP analogue resistant to angiotensin converting enzyme exhibits anti-fibrosis effects and improves heart function in mice after myocardial infarction
《Journal of Chinese Pharmaceutical Sciences》2015年第12期789-800,共12页陈建辉 马晓雯 张昭 张英启 苑媛 李萌 
National Science and Technology Major Projects(Invention and Creation of New Drugs)of China 2011ZXJ09104-01B;Xijing project 9XJZT13M17
To explore the effect of an Ac-SDKP analog on left ventricular remodeling after myocardial infarction,we synthesized the analog Ac-SD_DK_DP by replacing Asp and Lys with their D isomers.The biological activities of Ac...
关键词：Ac-SDKP ANALOGUE ANTI-FIBROSIS Myocardial infarction Heart failure 
Direct intercellular communications dominate the interaction between adipose-derived MSCs and myofibroblasts aqainst cardiac fibrosis被引量：9
《Protein & Cell》2015年第10期735-745,共11页Xiaokang Li Hui Zhao Chunxiao Qi Yang Zeng Feng Xu Yanan Du 
The onset of cardiac fibrosis post myocardial infarction greatly impairs the function of heart. Recent advances of cell transplantation showed great benefits to restore myocardial function, among which the mesenchymal...
关键词：cardiac fibrosis stem cell therapy adipose-derived mesenchymal stem cells myofibroblastscell-to-cell contact ANTI-FIBROSIS 
Anti-inflammation and anti-fibrosis actions of resveratrol on experimental pneumoconiosis
《中国药理学与毒理学杂志》2015年第S1期61-62,共2页JieLI Zong-kangZHANG YueQU Wing-NangLEUNG Bao-tingZHANG 
The project is supported by Pneumoconiosis Compensation Fund Board(6903114),HKSAR Government,Hong Kong
OBJECTIVE To investigate the therapeutic effects and related signaling pathways involved in the actions of resveratrol on experimental pneumoconiosis in vivo and in vitro.METHODS The pneumoconiosis animal model was in...
关键词：RESVERATROL ANTI-INFLAMMATION ANTI-FIBROSIS pneumo 
Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis被引量：32
《Acta Pharmacologica Sinica》2014年第8期1031-1044,共14页Jian-ping LI Yan GAO Shi-feng CHU Zhao ZHANG Cong-yuan XIA Zheng MOU Xiu-yun SONG Wen-bin HE Xiao-feng GUO Nai-hong CHEN 
This work was supported by National Natural Science Foun- dation of China grants （No 81274122, 81373510, 81273629, 81373998） and by the Beijing Natural Science Foundation （No 7131013）, Research Fund for the Doctoral Program of Higher Education of China （No 2012110613001）, National 863 Program of China （No 2012AA020303）, PCSIRT （No IRT1007）, National Key Sci-Tech Major Special Item （No 2012ZX09301002-004, 2012ZX09103101-006）, and Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study （No BZ0150）.
Aim： To investigate the anti-fibrosis effects of ginsenoside Rgl on alcohol- and CCl4-induced hepatic fibrosis in rats and to explore the mechanisms of the effects. Methods： Rats were given 6% alcohol in water and i...
关键词：ginseng GINSENOSIDE Rgl hepatic fibrosis hepatic stellate cells ALCOHOL CCL4 antioxidant enzymes Nrf2 pathway 
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